Advertisement
Research Article

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

  • Anna Aksenova equal contributor,

    equal contributor Contributed equally to this work with: Anna Aksenova, Kirill Volkov

    Affiliation: Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden

    Current address: Department of Biology, Tufts University, Medford, Massachusetts, United States of America

    X
  • Kirill Volkov equal contributor,

    equal contributor Contributed equally to this work with: Anna Aksenova, Kirill Volkov

    Affiliation: Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden

    Current address: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    X
  • Jaroslaw Maceluch,

    Affiliation: Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden

    X
  • Zachary F. Pursell,

    Affiliation: Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Heath, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

    Current address: Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America

    X
  • Igor B. Rogozin,

    Affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Thomas A. Kunkel,

    Affiliation: Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Heath, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

    X
  • Youri I. Pavlov,

    Affiliation: Eppley Institute for Research in Cancer, Department of Biochemistry and Molecular Biology, and Department of Microbiology and Pathology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Erik Johansson mail

    erik.johansson@medchem.umu.se

    Affiliation: Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden

    X
  • Published: November 18, 2010
  • DOI: 10.1371/journal.pgen.1001209

About the Authors

Anna Aksenova, Kirill Volkov, Jaroslaw Maceluch, Erik Johansson
Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden
Zachary F. Pursell, Thomas A. Kunkel
Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Heath, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America
Igor B. Rogozin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America
Youri I. Pavlov
Eppley Institute for Research in Cancer, Department of Biochemistry and Molecular Biology, and Department of Microbiology and Pathology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Corresponding Author

Email: erik.johansson@medchem.umu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AA KV YIP EJ. Performed the experiments: AA KV JM ZFP. Analyzed the data: AA KV JM ZFP IBR TAK YIP EJ. Contributed reagents/materials/analysis tools: IBR TAK YIP EJ. Wrote the paper: AA KV YIP EJ.