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Research Article

The Caenorhabditis elegans Kinesin-3 Motor UNC-104/KIF1A Is Degraded upon Loss of Specific Binding to Cargo

  • Jitendra Kumar equal contributor,

    equal contributor Contributed equally to this work with: Jitendra Kumar, Bikash C. Choudhary

    Affiliation: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India

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  • Bikash C. Choudhary equal contributor,

    equal contributor Contributed equally to this work with: Jitendra Kumar, Bikash C. Choudhary

    Affiliation: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India

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  • Raghu Metpally,

    Affiliation: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India

    Current address: University of Iowa, Institute for Clinical and Translational Science (ICTS) Administration, Iowa City, Iowa, United States of America

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  • Qun Zheng,

    Affiliation: Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Michael L. Nonet,

    Affiliation: Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Sowdhamini Ramanathan,

    Affiliation: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India

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  • Dieter R. Klopfenstein,

    Affiliations: Center for Molecular Physiology of the Brain, Georg August Universität Göttingen, Göttingen, Germany, Drittes Physikalisches Institut, Göttingen, Germany

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  • Sandhya P. Koushika mail

    koushika@ncbs.res.in

    Affiliation: National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India

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  • Published: November 04, 2010
  • DOI: 10.1371/journal.pgen.1001200

About the Authors

Jitendra Kumar, Bikash C. Choudhary, Raghu Metpally, Sowdhamini Ramanathan, Sandhya P. Koushika
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
Qun Zheng, Michael L. Nonet
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Dieter R. Klopfenstein
Center for Molecular Physiology of the Brain, Georg August Universität Göttingen, Göttingen, Germany
Dieter R. Klopfenstein
Drittes Physikalisches Institut, Göttingen, Germany

Corresponding Author

Email: koushika@ncbs.res.in

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SPK. Performed the experiments: JK BCC SPK. Analyzed the data: SPK. Contributed reagents/materials/analysis tools: RM QZ MLN SR DRK SPK. Wrote the paper: SPK.