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Research Article

Human-Specific Evolution and Adaptation Led to Major Qualitative Differences in the Variable Receptors of Human and Chimpanzee Natural Killer Cells

  • Laurent Abi-Rached,

    Affiliation: Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Achim K. Moesta,

    Affiliation: Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Raja Rajalingam,

    Affiliation: UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America

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  • Lisbeth A. Guethlein,

    Affiliation: Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Peter Parham mail

    peropa@stanford.edu

    Affiliation: Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: November 04, 2010
  • DOI: 10.1371/journal.pgen.1001192

About the Authors

Laurent Abi-Rached, Achim K. Moesta, Lisbeth A. Guethlein, Peter Parham
Department of Structural Biology, Stanford University School of Medicine, Stanford, California, United States of America
Raja Rajalingam
UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: peropa@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LAR PP. Performed the experiments: LAR. Analyzed the data: LAR. Wrote the paper: LAR PP. Contributed to the MHC analysis and KIR typing study: AKM. Contributed to the chimpanzee KIR typing analysis: RR. Contributed to the analysis of the KIR genomic sequences and to the human-chimpanzee haplotype comparisons: LAG.