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Research Article

Allele-Specific Down-Regulation of RPTOR Expression Induced by Retinoids Contributes to Climate Adaptations

  • Chang Sun,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Catherine Southard,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • David B. Witonsky,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Ralf Kittler,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

    Current address: McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Anna Di Rienzo mail

    dirienzo@bsd.uchicago.edu

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Published: October 28, 2010
  • DOI: 10.1371/journal.pgen.1001178

About the Authors

Chang Sun, Catherine Southard, David B. Witonsky, Ralf Kittler, Anna Di Rienzo
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: dirienzo@bsd.uchicago.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: C Sun, R Kittler, A Di Rienzo. Performed the experiments: C Sun, C Southard. Analyzed the data: C Sun, DB Witonsky, R Kittler, A Di Rienzo. Wrote the paper: C Sun, R Kittler, A Di Rienzo.