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Research Article

Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy

  • Klaus Stark,

    Affiliation: Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany

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  • Ulrike B. Esslinger,

    Affiliation: Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany

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  • Wibke Reinhard,

    Affiliation: Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany

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  • George Petrov,

    Affiliations: Institute for Gender in Medicine, Center for Cardiovascular Research, Charité Campus Mitte, Berlin, Germany, Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Berlin, Germany

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  • Thomas Winkler,

    Affiliation: Institute of Epidemiology, Public Health, and Gender Studies, University of Regensburg, Regensburg, Germany

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  • Michel Komajda,

    Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S956, University Pierre et Marie Curie (Paris 6), Institut de Cardiologie, Département de Génétique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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  • Richard Isnard,

    Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S956, University Pierre et Marie Curie (Paris 6), Institut de Cardiologie, Département de Génétique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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  • Philippe Charron,

    Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S956, University Pierre et Marie Curie (Paris 6), Institut de Cardiologie, Département de Génétique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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  • Eric Villard,

    Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S956, University Pierre et Marie Curie (Paris 6), Institut de Cardiologie, Département de Génétique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France

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  • François Cambien,

    Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-S937, University Pierre et Marie Curie (Paris 6), Paris, France

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  • Laurence Tiret,

    Affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-S937, University Pierre et Marie Curie (Paris 6), Paris, France

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  • Marie-Claude Aumont,

    Affiliation: Service de Cardiologie, Hôpital Bichat, AP-HP, Paris, France

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  • Olivier Dubourg,

    Affiliation: Service de Cardiologie, Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne, France

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  • Jean-Noël Trochu,

    Affiliation: Service de Cardiologie, Hôpital Laennec, Nantes, France

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  • Laurent Fauchier,

    Affiliation: Service de Cardiologie B et Laboratoire d'Electrophysiologie Cardiaque, Pole Cœur Thorax Vasculaire Hémostase, Centre Hospitalier Universitaire Trousseau, Tours, France

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  • Pascal DeGroote,

    Affiliation: Service de Cardiologie, Hôpital Cardiologique, Lille, France

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  • Anette Richter,

    Affiliation: Klinik für Innere Medizin I - Kardiologie, Philipps-Universität Marburg, Marburg, Germany

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  • Bernhard Maisch,

    Affiliation: Klinik für Innere Medizin I - Kardiologie, Philipps-Universität Marburg, Marburg, Germany

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  • Thomas Wichter,

    Affiliation: Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitätsklinikum Münster, Münster, Germany

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  • Christa Zollbrecht,

    Affiliation: Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany

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  • Martina Grassl,

    Affiliation: Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany

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  • Heribert Schunkert,

    Affiliation: Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany

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  • Patrick Linsel-Nitschke,

    Affiliation: Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany

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  • Jeanette Erdmann,

    Affiliation: Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany

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  • Jens Baumert,

    Affiliation: Institute of Epidemiology, HelmholtzZentrum München, München-Neuherberg, Germany

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  • Thomas Illig,

    Affiliation: Institute of Epidemiology, HelmholtzZentrum München, München-Neuherberg, Germany

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  • Norman Klopp,

    Affiliation: Institute of Epidemiology, HelmholtzZentrum München, München-Neuherberg, Germany

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  • H.-Erich Wichmann,

    Affiliation: Institute of Epidemiology, HelmholtzZentrum München, München-Neuherberg, Germany

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  • Christa Meisinger,

    Affiliations: Institute of Epidemiology, HelmholtzZentrum München, München-Neuherberg, Germany, Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany

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  • Wolfgang Koenig,

    Affiliation: Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany

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  • Peter Lichtner,

    Affiliation: Institute of Human Genetics, HelmholtzZentrum München, München-Neuherberg, Germany

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  • Thomas Meitinger,

    Affiliations: Institute of Human Genetics, HelmholtzZentrum München, München-Neuherberg, Germany, Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, München, Germany

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  • Arne Schillert,

    Affiliation: Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany

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  • Inke R. König,

    Affiliation: Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany

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  • Roland Hetzer,

    Affiliation: Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Berlin, Germany

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  • Iris M. Heid,

    Affiliations: Institute of Epidemiology, Public Health, and Gender Studies, University of Regensburg, Regensburg, Germany, Institute of Epidemiology, HelmholtzZentrum München, München-Neuherberg, Germany

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  • Vera Regitz-Zagrosek,

    Affiliation: Institute for Gender in Medicine, Center for Cardiovascular Research, Charité Campus Mitte, Berlin, Germany

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  • Christian Hengstenberg mail

    christian.hengstenberg@klinik.uni-regensburg.de

    Affiliation: Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany

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  • Published: October 21, 2010
  • DOI: 10.1371/journal.pgen.1001167

About the Authors

Klaus Stark, Ulrike B. Esslinger, Wibke Reinhard, Christa Zollbrecht, Martina Grassl, Christian Hengstenberg
Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany
George Petrov, Vera Regitz-Zagrosek
Institute for Gender in Medicine, Center for Cardiovascular Research, Charité Campus Mitte, Berlin, Germany
George Petrov, Roland Hetzer
Department of Cardiothoracic and Vascular Surgery, German Heart Institute Berlin, Berlin, Germany
Thomas Winkler, Iris M. Heid
Institute of Epidemiology, Public Health, and Gender Studies, University of Regensburg, Regensburg, Germany
Michel Komajda, Richard Isnard, Philippe Charron, Eric Villard
Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S956, University Pierre et Marie Curie (Paris 6), Institut de Cardiologie, Département de Génétique, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France
François Cambien, Laurence Tiret
Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-S937, University Pierre et Marie Curie (Paris 6), Paris, France
Marie-Claude Aumont
Service de Cardiologie, Hôpital Bichat, AP-HP, Paris, France
Olivier Dubourg
Service de Cardiologie, Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne, France
Jean-Noël Trochu
Service de Cardiologie, Hôpital Laennec, Nantes, France
Laurent Fauchier
Service de Cardiologie B et Laboratoire d'Electrophysiologie Cardiaque, Pole Cœur Thorax Vasculaire Hémostase, Centre Hospitalier Universitaire Trousseau, Tours, France
Pascal DeGroote
Service de Cardiologie, Hôpital Cardiologique, Lille, France
Anette Richter, Bernhard Maisch
Klinik für Innere Medizin I - Kardiologie, Philipps-Universität Marburg, Marburg, Germany
Thomas Wichter
Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitätsklinikum Münster, Münster, Germany
Heribert Schunkert, Patrick Linsel-Nitschke, Jeanette Erdmann
Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany
Jens Baumert, Thomas Illig, Norman Klopp, H.-Erich Wichmann, Christa Meisinger, Iris M. Heid
Institute of Epidemiology, HelmholtzZentrum München, München-Neuherberg, Germany
Christa Meisinger
Central Hospital of Augsburg, MONICA/KORA Myocardial Infarction Registry, Augsburg, Germany
Wolfgang Koenig
Department of Internal Medicine II – Cardiology, University of Ulm Medical Center, Ulm, Germany
Peter Lichtner, Thomas Meitinger
Institute of Human Genetics, HelmholtzZentrum München, München-Neuherberg, Germany
Thomas Meitinger
Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, München, Germany
Arne Schillert, Inke R. König
Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany

Corresponding Author

Email: christian.hengstenberg@klinik.uni-regensburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K Stark, C Hengstenberg. Performed the experiments: K Stark, UB Esslinger, C Zollbrecht, N Klopp, P Lichtner, T Meitinger. Analyzed the data: K Stark, T Winkler, F Cambien, J Baumert, A Schillert, IR König, IM Heid. Contributed reagents/materials/analysis tools: K Stark, G Petrov, M Komajda, R Isnard, P Charron, E Villard, F Cambien, L Tiret, MC Aumont, O Dubourg, JN Trouchu, L Fauchier, P DeGroote, A Richter, B Maisch, T Wichter, M Grassl, H Schunkert, P Linsel-Nitschke, J Erdmann, T Illig, HE Wichmann, C Meisinger, W Koening, R Hetzer, IM Heid, V Regitz-Zagrosek, C Hengstenberg. Wrote the paper: K Stark, UB Esslinger, W Reinhard, IM Heid, V Regitz-Zagrosek, C Hengstenberg.