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Research Article

Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions

  • Kouji Hirota,

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Eiichiro Sonoda,

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Takuo Kawamoto,

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Akira Motegi,

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Chikahide Masutani,

    Affiliation: Solution-Oriented Research for Science and Technology (SORST), Japan Science and Technology Agency, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

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  • Fumio Hanaoka,

    Affiliation: Solution-Oriented Research for Science and Technology (SORST), Japan Science and Technology Agency, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

    Current address: Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan

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  • Dávid Szüts,

    Affiliation: St. George's, University of London, London, United Kingdom

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  • Shigenori Iwai,

    Affiliation: Division of Chemistry, Graduate School of Engineering Science, Osaka University, Osaka, Japan

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  • Julian E. Sale,

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Alan Lehmann,

    Affiliation: Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom

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  • Shunichi Takeda mail

    stakeda@rg.med.kyoto-u.ac.jp

    Affiliation: CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Published: October 07, 2010
  • DOI: 10.1371/journal.pgen.1001151

About the Authors

Kouji Hirota, Eiichiro Sonoda, Takuo Kawamoto, Akira Motegi, Shunichi Takeda
CREST Research Project, Japan Science and Technology, Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Chikahide Masutani, Fumio Hanaoka
Solution-Oriented Research for Science and Technology (SORST), Japan Science and Technology Agency, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
Dávid Szüts
St. George's, University of London, London, United Kingdom
Shigenori Iwai
Division of Chemistry, Graduate School of Engineering Science, Osaka University, Osaka, Japan
Julian E. Sale
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
Alan Lehmann
Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom

Corresponding Author

Email: stakeda@rg.med.kyoto-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KH ES TK AM ST. Performed the experiments: KH ES TK AM. Analyzed the data: KH ES TK AM ST. Contributed reagents/materials/analysis tools: CM FH DS SI JES AL. Wrote the paper: KH ES TK AM ST.