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Research Article

The Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions

  • Michal Letek,

    Affiliation: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom

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  • Patricia González,

    Affiliations: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Irish Equine Centre, Johnstown, Naas, Ireland

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  • Iain MacArthur,

    Affiliations: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Irish Equine Centre, Johnstown, Naas, Ireland, Department of Pathobiology, University of Guelph, Guelph, Canada

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  • Héctor Rodríguez,

    Affiliations: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Irish Equine Centre, Johnstown, Naas, Ireland

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  • Tom C. Freeman,

    Affiliation: Division of Genetics and Genomics, Roslin BioCentre, University of Edinburgh, Edinburgh, United Kingdom

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  • Ana Valero-Rello,

    Affiliations: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Irish Equine Centre, Johnstown, Naas, Ireland

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  • Mónica Blanco,

    Affiliations: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Irish Equine Centre, Johnstown, Naas, Ireland

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  • Tom Buckley,

    Affiliation: Irish Equine Centre, Johnstown, Naas, Ireland

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  • Inna Cherevach,

    Affiliation: Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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  • Ruth Fahey,

    Affiliation: School of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, Ireland

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  • Alexia Hapeshi,

    Affiliation: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom

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  • Jolyon Holdstock,

    Affiliation: Oxford Gene Technology, Begbroke Science Park, Oxford, United Kingdom

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  • Desmond Leadon,

    Affiliation: Irish Equine Centre, Johnstown, Naas, Ireland

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  • Jesús Navas,

    Affiliation: Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain

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  • Alain Ocampo,

    Affiliation: Irish Equine Centre, Johnstown, Naas, Ireland

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  • Michael A. Quail,

    Affiliation: Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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  • Mandy Sanders,

    Affiliation: Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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  • Mariela M. Scortti,

    Affiliations: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Departamento de Bioquímica y Biología Molecular IV, Universidad Complutense, Madrid, Spain

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  • John F. Prescott,

    Affiliation: Department of Pathobiology, University of Guelph, Guelph, Canada

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  • Ursula Fogarty,

    Affiliation: Irish Equine Centre, Johnstown, Naas, Ireland

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  • Wim G. Meijer,

    Affiliation: School of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, Ireland

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  • Julian Parkhill,

    Affiliation: Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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  • Stephen D. Bentley,

    Affiliation: Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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  • José A. Vázquez-Boland mail

    v.boland@ed.ac.uk

    Affiliations: Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Grupo de Patogenómica Bacteriana, Universidad de León, León, Spain

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  • Published: September 30, 2010
  • DOI: 10.1371/journal.pgen.1001145

About the Authors

Michal Letek, Patricia González, Iain MacArthur, Héctor Rodríguez, Ana Valero-Rello, Mónica Blanco, Alexia Hapeshi, Mariela M. Scortti, José A. Vázquez-Boland
Microbial Pathogenesis Unit, Centres for Infectious Diseases and Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, United Kingdom
Patricia González, Iain MacArthur, Héctor Rodríguez, Ana Valero-Rello, Mónica Blanco, Tom Buckley, Desmond Leadon, Alain Ocampo, Ursula Fogarty
Irish Equine Centre, Johnstown, Naas, Ireland
Iain MacArthur, John F. Prescott
Department of Pathobiology, University of Guelph, Guelph, Canada
Tom C. Freeman
Division of Genetics and Genomics, Roslin BioCentre, University of Edinburgh, Edinburgh, United Kingdom
Inna Cherevach, Michael A. Quail, Mandy Sanders, Julian Parkhill, Stephen D. Bentley
Pathogen Genomics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
Ruth Fahey, Wim G. Meijer
School of Biomolecular and Biomedical Sciences, University College Dublin, Dublin, Ireland
Jolyon Holdstock
Oxford Gene Technology, Begbroke Science Park, Oxford, United Kingdom
Jesús Navas
Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain
Mariela M. Scortti
Departamento de Bioquímica y Biología Molecular IV, Universidad Complutense, Madrid, Spain
José A. Vázquez-Boland
Grupo de Patogenómica Bacteriana, Universidad de León, León, Spain

Corresponding Author

Email: v.boland@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived research: JAVB JFP WGM JP SDB. Performed research: ML PG HR IC AH JH JN MAQ MS. Analyzed data: ML IM TCF AVR MB TB RF DL JN AO MMS UF WGM JP SDB JAVB. Wrote the paper: JAVB ML. Prepared the manuscript: JAVB ML MMS.