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Research Article

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

  • Adam C. Naj,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Gary W. Beecham,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Eden R. Martin,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Paul J. Gallins,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Eric H. Powell,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Ioanna Konidari,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Patrice L. Whitehead,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Guiqing Cai,

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Vahram Haroutunian,

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • William K. Scott,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Jeffery M. Vance,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Michael A. Slifer,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Harry E. Gwirtsman,

    Affiliation: Veterans Affairs Medical Center, Nashville, Tennessee, United States of America

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  • John R. Gilbert,

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Jonathan L. Haines equal contributor,

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    Affiliation: Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Joseph D. Buxbaum equal contributor,

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    Affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Margaret A. Pericak-Vance equal contributor mail

    equal contributor Contributed equally to this work with: Jonathan L. Haines, Joseph D. Buxbaum, Margaret A. Pericak-Vance

    mpericak@med.miami.edu

    Affiliation: Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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  • Published: September 23, 2010
  • DOI: 10.1371/journal.pgen.1001130

About the Authors

Adam C. Naj, Gary W. Beecham, Eden R. Martin, Paul J. Gallins, Eric H. Powell, Ioanna Konidari, Patrice L. Whitehead, William K. Scott, Jeffery M. Vance, Michael A. Slifer, John R. Gilbert, Margaret A. Pericak-Vance
Dr. John T. Macdonald Foundation Department of Human Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
Guiqing Cai, Vahram Haroutunian, Joseph D. Buxbaum
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America
Harry E. Gwirtsman
Veterans Affairs Medical Center, Nashville, Tennessee, United States of America
Jonathan L. Haines
Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Corresponding Author

Email: mpericak@med.miami.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ACN GWB ERM WKS JMV MAS JRG JLH JDB MAPV. Performed the experiments: IK PLW JRG JLH JDB MAPV. Analyzed the data: ACN GWB PJG EHP MAS JLH JDB MAPV. Contributed reagents/materials/analysis tools: ACN GWB GC VH WKS JMV HEG JLH JDB MAPV. Wrote the paper: ACN GWB ERM PJG EHP IK PLW GC VH WKS JMV MAS HEG JRG JLH JDB MAPV.