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Research Article

Genetic Deletion of the Desmosomal Component Desmoplakin Promotes Tumor Microinvasion in a Mouse Model of Pancreatic Neuroendocrine Carcinogenesis

  • Matthew G. H. Chun,

    Affiliations: Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America, Program in Biological Sciences, University of California San Francisco, San Francisco, California, United States of America

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  • Douglas Hanahan mail

    dh@ucsf.edu

    Affiliations: Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America, Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

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  • Published: September 16, 2010
  • DOI: 10.1371/journal.pgen.1001120

About the Authors

Matthew G. H. Chun, Douglas Hanahan
Department of Biochemistry and Biophysics, Helen Diller Family Comprehensive Cancer Center, and Diabetes Center, University of California San Francisco, San Francisco, California, United States of America
Matthew G. H. Chun
Program in Biological Sciences, University of California San Francisco, San Francisco, California, United States of America
Douglas Hanahan
Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

Corresponding Author

Email: dh@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MGHC DH. Performed the experiments: MGHC. Analyzed the data: MGHC DH. Wrote the paper: MGHC DH.