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Research Article

An Immune Response Network Associated with Blood Lipid Levels

  • Michael Inouye mail,

    inouye@wehi.edu.au

    Affiliations: Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands

    Current address: Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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  • Kaisa Silander,

    Affiliation: Institute of Molecular Medicine FIMM, University of Helsinki and Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland

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  • Eija Hamalainen,

    Affiliation: Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

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  • Veikko Salomaa,

    Affiliation: Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Kennet Harald,

    Affiliation: Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Pekka Jousilahti,

    Affiliation: Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Satu Männistö,

    Affiliation: Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland

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  • Johan G. Eriksson,

    Affiliations: Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland, Vasa Central Hospital, Vasa, Finland, Folkhälsan Research Centre, Helsinki, Finland

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  • Janna Saarela,

    Affiliations: Institute of Molecular Medicine FIMM, University of Helsinki and Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland, Institute of Molecular Medicine FIMM Technology Center, University of Helsinki, Helsinki, Finland

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  • Samuli Ripatti,

    Affiliation: Institute of Molecular Medicine FIMM, University of Helsinki and Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland

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  • Markus Perola,

    Affiliation: Institute of Molecular Medicine FIMM, University of Helsinki and Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland

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  • Gert-Jan B. van Ommen,

    Affiliation: Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands

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  • Marja-Riitta Taskinen,

    Affiliation: Department of Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

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  • Aarno Palotie,

    Affiliations: Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Institute of Molecular Medicine FIMM, University of Helsinki and Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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  • Emmanouil T. Dermitzakis,

    Affiliations: Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

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  • Leena Peltonen †

    † Deceased.

    Affiliations: Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Institute of Molecular Medicine FIMM, University of Helsinki and Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Published: September 09, 2010
  • DOI: 10.1371/journal.pgen.1001113

About the Authors

Michael Inouye, Eija Hamalainen, Aarno Palotie, Emmanouil T. Dermitzakis, Leena Peltonen
Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
Michael Inouye, Gert-Jan B. van Ommen
Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
Kaisa Silander, Janna Saarela, Samuli Ripatti, Markus Perola, Aarno Palotie, Leena Peltonen
Institute of Molecular Medicine FIMM, University of Helsinki and Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland
Veikko Salomaa, Kennet Harald, Pekka Jousilahti, Satu Männistö, Johan G. Eriksson
Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland
Johan G. Eriksson
Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
Johan G. Eriksson
Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland
Johan G. Eriksson
Vasa Central Hospital, Vasa, Finland
Johan G. Eriksson
Folkhälsan Research Centre, Helsinki, Finland
Janna Saarela
Institute of Molecular Medicine FIMM Technology Center, University of Helsinki, Helsinki, Finland
Marja-Riitta Taskinen
Department of Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Aarno Palotie, Leena Peltonen
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Aarno Palotie
Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Emmanouil T. Dermitzakis
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

Corresponding Author

Email: inouye@wehi.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MI KS MP GJBvO MRT AP ETD LP. Performed the experiments: KS EH VS KH PJ SM JS. Analyzed the data: MI SR. Contributed reagents/materials/analysis tools: MI VS KH JGE ETD. Wrote the paper: MI ETD LP.