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Research Article

Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

  • Chen-Hua Chuang,

    Affiliation: Department of Biomedical Sciences and Center for Vertebrate Genomics, Cornell University, Ithaca, New York, United States of America

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  • Marsha D. Wallace,

    Affiliation: Department of Biomedical Sciences and Center for Vertebrate Genomics, Cornell University, Ithaca, New York, United States of America

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  • Christian Abratte,

    Affiliation: Department of Biomedical Sciences and Center for Vertebrate Genomics, Cornell University, Ithaca, New York, United States of America

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  • Teresa Southard,

    Affiliation: Department of Biomedical Sciences and Center for Vertebrate Genomics, Cornell University, Ithaca, New York, United States of America

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  • John C. Schimenti mail

    jcs92@cornell.edu

    Affiliation: Department of Biomedical Sciences and Center for Vertebrate Genomics, Cornell University, Ithaca, New York, United States of America

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  • Published: September 09, 2010
  • DOI: 10.1371/journal.pgen.1001110

About the Authors

Chen-Hua Chuang, Marsha D. Wallace, Christian Abratte, Teresa Southard, John C. Schimenti
Department of Biomedical Sciences and Center for Vertebrate Genomics, Cornell University, Ithaca, New York, United States of America

Corresponding Author

Email: jcs92@cornell.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CHC JCS. Performed the experiments: CHC MDW CA. Analyzed the data: CHC MDW TS JCS. Wrote the paper: CHC TS JCS.