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Research Article

A Single cis Element Maintains Repression of the Key Developmental Regulator Gata2

  • Jonathan W. Snow,

    Affiliations: Division of Hematology-Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Jennifer J. Trowbridge,

    Affiliations: Division of Hematology-Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Boston, Massachusetts, United States of America

    X
  • Tohru Fujiwara,

    Affiliation: Wisconsin Institutes for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

    X
  • Nikla E. Emambokus,

    Affiliations: Division of Hematology-Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Jeffrey A. Grass,

    Affiliation: Wisconsin Institutes for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

    X
  • Stuart H. Orkin mail,

    orkin@bloodgroup.tch.harvard.edu (SHO); ehbresni@wisc.edu (EHB)

    Affiliations: Division of Hematology-Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

    X
  • Emery H. Bresnick mail

    orkin@bloodgroup.tch.harvard.edu (SHO); ehbresni@wisc.edu (EHB)

    Affiliation: Wisconsin Institutes for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

    X
  • Published: September 09, 2010
  • DOI: 10.1371/journal.pgen.1001103

About the Authors

Jonathan W. Snow, Jennifer J. Trowbridge, Nikla E. Emambokus, Stuart H. Orkin
Division of Hematology-Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America
Jonathan W. Snow, Jennifer J. Trowbridge, Nikla E. Emambokus, Stuart H. Orkin
Harvard Medical School, Boston, Massachusetts, United States of America
Jennifer J. Trowbridge, Stuart H. Orkin
Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Jennifer J. Trowbridge, Stuart H. Orkin
Harvard Stem Cell Institute, Boston, Massachusetts, United States of America
Tohru Fujiwara, Jeffrey A. Grass, Emery H. Bresnick
Wisconsin Institutes for Medical Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
Stuart H. Orkin
Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JWS SHO EHB. Performed the experiments: JWS JJT TF NEE JAG EHB. Analyzed the data: JWS JJT TF SHO EHB. Contributed reagents/materials/analysis tools: NEE JAG. Wrote the paper: JWS JJT SHO EHB.