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Research Article

The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny

  • Andreas Rechtsteiner equal contributor,

    equal contributor Contributed equally to this work with: Andreas Rechtsteiner, Sevinc Ercan, Teruaki Takasaki

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

    X
  • Sevinc Ercan equal contributor,

    equal contributor Contributed equally to this work with: Andreas Rechtsteiner, Sevinc Ercan, Teruaki Takasaki

    Affiliation: Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Teruaki Takasaki equal contributor,

    equal contributor Contributed equally to this work with: Andreas Rechtsteiner, Sevinc Ercan, Teruaki Takasaki

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

    X
  • Taryn M. Phippen,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

    X
  • Thea A. Egelhofer,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

    X
  • Wenchao Wang,

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

    Current address: Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Hiroshi Kimura,

    Affiliation: Graduate School for Frontier Biosciences, Osaka University, Suita, Osaka, Japan

    X
  • Jason D. Lieb mail,

    strome@biology.ucsc.edu (SS); jlieb@bio.unc.edu (JDL)

    Affiliation: Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Susan Strome mail

    strome@biology.ucsc.edu (SS); jlieb@bio.unc.edu (JDL)

    Affiliation: Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America

    X
  • Published: September 02, 2010
  • DOI: 10.1371/journal.pgen.1001091

About the Authors

Andreas Rechtsteiner, Teruaki Takasaki, Taryn M. Phippen, Thea A. Egelhofer, Wenchao Wang, Susan Strome
Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
Sevinc Ercan, Jason D. Lieb
Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Hiroshi Kimura
Graduate School for Frontier Biosciences, Osaka University, Suita, Osaka, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AR SE TT TMP JDL SS. Performed the experiments: TT TMP TAE. Analyzed the data: AR SE TT. Contributed reagents/materials/analysis tools: WW HK. Wrote the paper: AR SE TT JDL SS.