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Research Article

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

  • Alexandre Benedetto,

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Children's Hospital, Vanderbilt University, Nashville, Tennessee, United States of America, London Centre for Nanotechnology, University College London, London, United Kingdom

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  • Catherine Au,

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Daiana Silva Avila,

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Children's Hospital, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Dejan Milatovic,

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Michael Aschner mail

    michael.aschner@vanderbilt.edu

    Affiliations: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America, Children's Hospital, Vanderbilt University, Nashville, Tennessee, United States of America, Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Published: August 26, 2010
  • DOI: 10.1371/journal.pgen.1001084

About the Authors

Alexandre Benedetto, Catherine Au, Daiana Silva Avila, Dejan Milatovic, Michael Aschner
Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America
Alexandre Benedetto, Daiana Silva Avila, Michael Aschner
Children's Hospital, Vanderbilt University, Nashville, Tennessee, United States of America
Alexandre Benedetto
London Centre for Nanotechnology, University College London, London, United Kingdom
Catherine Au, Dejan Milatovic, Michael Aschner
Center for Molecular Toxicology, Vanderbilt University, Nashville, Tennessee, United States of America

Corresponding Author

Email: michael.aschner@vanderbilt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB CA DSdA MA. Performed the experiments: AB CA DSdA. Analyzed the data: AB CA DSdA DM. Contributed reagents/materials/analysis tools: DM MA. Wrote the paper: AB MA.