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Research Article

Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila

  • Ana Griciuc,

    Affiliation: Department of Protein Science, Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Neuherberg, Germany

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  • Liviu Aron mail,

    laron@neuro.mpg.de (LA); marius.ueffing@helmholtz-muenchen.de (MU)

    Affiliation: Department of Molecular Neurobiology, Max-Planck-Institute of Neurobiology, Martinsried, Germany

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  • Michel J. Roux,

    Affiliation: Department of Neurobiology and Genetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France

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  • Rüdiger Klein,

    Affiliation: Department of Molecular Neurobiology, Max-Planck-Institute of Neurobiology, Martinsried, Germany

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  • Angela Giangrande,

    Affiliation: Department of Cell and Developmental Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France

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  • Marius Ueffing mail

    laron@neuro.mpg.de (LA); marius.ueffing@helmholtz-muenchen.de (MU)

    Affiliations: Department of Protein Science, Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Neuherberg, Germany, Institute for Ophthalmic Research, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany

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  • Published: August 26, 2010
  • DOI: 10.1371/journal.pgen.1001075

About the Authors

Ana Griciuc, Marius Ueffing
Department of Protein Science, Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Neuherberg, Germany
Liviu Aron, Rüdiger Klein
Department of Molecular Neurobiology, Max-Planck-Institute of Neurobiology, Martinsried, Germany
Michel J. Roux
Department of Neurobiology and Genetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France
Angela Giangrande
Department of Cell and Developmental Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France
Marius Ueffing
Institute for Ophthalmic Research, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: A Griciuc, L Aron, M Ueffing. Performed the experiments: A Griciuc. Analyzed the data: A Griciuc, L Aron, R Klein, A Giangrande, M Ueffing. Contributed reagents/materials/analysis tools: L Aron, R Klein, A Giangrande. Wrote the paper: A Griciuc, L Aron, M Ueffing. Performed and analyzed ERG experiments: MJ Roux.