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Research Article

Microtubule Actin Crosslinking Factor 1 Regulates the Balbiani Body and Animal-Vegetal Polarity of the Zebrafish Oocyte

  • Tripti Gupta,

    Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Florence L. Marlow,

    Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Deborah Ferriola,

    Affiliations: Generation Biotech, Lawrenceville, New Jersey, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Katarzyna Mackiewicz,

    Affiliations: Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Johannes Dapprich,

    Affiliation: Generation Biotech, Lawrenceville, New Jersey, United States of America

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  • Dimitri Monos,

    Affiliations: Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Mary C. Mullins mail

    mullins@mail.med.upenn.edu

    Affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: August 19, 2010
  • DOI: 10.1371/journal.pgen.1001073

About the Authors

Tripti Gupta, Florence L. Marlow, Mary C. Mullins
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Deborah Ferriola, Johannes Dapprich
Generation Biotech, Lawrenceville, New Jersey, United States of America
Deborah Ferriola, Katarzyna Mackiewicz, Dimitri Monos
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Deborah Ferriola, Katarzyna Mackiewicz, Dimitri Monos
Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: mullins@mail.med.upenn.edu

Competing Interests

One author (JD) is the founder of Generation Biotech and an inventor of haplotype-specific extraction, and another author (DF) was an employee of Generation Biotech at the time of the work. DM developed the Region Specific Extraction method in collaboration with Generation Biotech.

Author Contributions

Conceived and designed the experiments: TG FLM DF JD DM MCM. Performed the experiments: TG FLM DF KM. Analyzed the data: TG FLM DF KM JD DM MCM. Contributed reagents/materials/analysis tools: JD DM MCM. Wrote the paper: TG DF JD DM MCM.