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Research Article

Conserved Role of unc-79 in Ethanol Responses in Lightweight Mutant Mice

  • David J. Speca mail,

    dave.speca@gmail.com (DS); slm@gallo.ucsf.edu (SLM)

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

    Current address: Department of Pharmacology, University of California Davis, Davis, California, United States of America

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  • Daisuke Chihara,

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

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  • Amir M. Ashique,

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

    Current address: Department of Molecular Biology, Genentech, South San Francisco, California, United States of America

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  • M. Scott Bowers,

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

    Current address: Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, United States of America

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  • Jonathan T. Pierce-Shimomura,

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

    Current address: College of Natural Sciences, Section of Neurobiology, University of Texas, Austin, Texas, United States of America

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  • Jungsoo Lee,

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

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  • Nusrat Rabbee,

    Affiliation: Department of Statistics, University of California Berkeley, Berkeley, California, United States of America

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  • Terence P. Speed,

    Affiliation: Department of Statistics, University of California Berkeley, Berkeley, California, United States of America

    Current address: Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

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  • Rodrigo J. Gularte,

    Affiliation: Department of Animal Science, University of California Davis, Davis, California, United States of America

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  • James Chitwood,

    Affiliation: Department of Animal Science, University of California Davis, Davis, California, United States of America

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  • Juan F. Medrano,

    Affiliation: Department of Animal Science, University of California Davis, Davis, California, United States of America

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  • Mark Liao,

    Affiliation: Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

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  • James M. Sonner,

    Affiliation: Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

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  • Edmond I. Eger II,

    Affiliation: Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

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  • Andrew S. Peterson equal contributor,

    equal contributor Contributed equally to this work with: Andrew S. Peterson, Steven L. McIntire

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

    Current address: Department of Molecular Biology, Genentech, South San Francisco, California, United States of America

    X
  • Steven L. McIntire equal contributor mail

    equal contributor Contributed equally to this work with: Andrew S. Peterson, Steven L. McIntire

    dave.speca@gmail.com (DS); slm@gallo.ucsf.edu (SLM)

    Affiliation: Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America

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  • Published: August 12, 2010
  • DOI: 10.1371/journal.pgen.1001057

About the Authors

David J. Speca, Daisuke Chihara, Amir M. Ashique, M. Scott Bowers, Jonathan T. Pierce-Shimomura, Jungsoo Lee, Andrew S. Peterson, Steven L. McIntire
Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America
Nusrat Rabbee, Terence P. Speed
Department of Statistics, University of California Berkeley, Berkeley, California, United States of America
Rodrigo J. Gularte, James Chitwood, Juan F. Medrano
Department of Animal Science, University of California Davis, Davis, California, United States of America
Mark Liao, James M. Sonner, Edmond I. Eger II
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

EIE is a paid consultant of Baxter Healthcare.

Author Contributions

Conceived and designed the experiments: DJS TPS JFM EIEI ASP SLM. Performed the experiments: DJS DC AMA MSB JL NR RJG JC ML JMS EIEI. Analyzed the data: DJS DC MSB JTPS JL NR TPS RJG JFM JMS EIEI ASP SLM. Wrote the paper: DJS DC AMA MSB JTPS JL TPS RJG JC JFM EIEI ASP SLM.