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Research Article

The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

  • Chao Agnes Hsiung equal contributor mail,

    equal contributor Contributed equally to this work with: Chao Agnes Hsiung, Qing Lan

    hsiung@nhri.org.tw (CAH); qingl@mail.nih.gov (QL)

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Qing Lan equal contributor mail,

    equal contributor Contributed equally to this work with: Chao Agnes Hsiung, Qing Lan

    hsiung@nhri.org.tw (CAH); qingl@mail.nih.gov (QL)

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Yun-Chul Hong,

    Affiliations: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea

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  • Chien-Jen Chen,

    Affiliations: Genomics Research Center, Academia Sinica, Taipei, Taiwan, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan

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  • H. Dean Hosgood III,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • I-Shou Chang,

    Affiliation: National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan

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  • Nilanjan Chatterjee,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Paul Brennan,

    Affiliation: International Agency for Research on Cancer, Lyon, France

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  • Chen Wu,

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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  • Wei Zheng,

    Affiliation: Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Gee-Chen Chang,

    Affiliations: Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan, School of Medicine, China Medical University, Taichung, Taiwan

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  • Tangchun Wu,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • Jae Yong Park,

    Affiliations: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea, Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea, Cancer Research Center, Kyungpook National University Hospital, Daegu, Republic of Korea

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  • Chin-Fu Hsiao,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Yeul Hong Kim,

    Affiliations: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain, Korea University College of Medicine, Seoul, Republic of Korea, Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea

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  • Hongbing Shen,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Adeline Seow,

    Affiliation: Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

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  • Meredith Yeager,

    Affiliations: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America

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  • Ying-Huang Tsai,

    Affiliations: Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taiwan, Department of Respiratory Care, Chang Gung University, Taiwan

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  • Young Tae Kim,

    Affiliations: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea

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  • Wong-Ho Chow,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Huan Guo,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • Wen-Chang Wang,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Sook Whan Sung,

    Affiliations: Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea, Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Geongi-do, Republic of Korea

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  • Zhibin Hu,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Kuan-Yu Chen,

    Affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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  • Joo Hyun Kim,

    Affiliation: Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea

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  • Ying Chen,

    Affiliation: Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore

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  • Liming Huang,

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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  • Kyoung-Mu Lee,

    Affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

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  • Yen-Li Lo,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Yu-Tang Gao,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Jin Hee Kim,

    Affiliations: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea

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  • Li Liu,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • Ming-Shyan Huang,

    Affiliation: Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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  • Tae Hoon Jung,

    Affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

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  • Guangfu Jin,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Neil Caporaso,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Dianke Yu,

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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  • Chang Ho Kim,

    Affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

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  • Wu-Chou Su,

    Affiliation: Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan

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  • Xiao-Ou Shu,

    Affiliation: Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Ping Xu,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • In-San Kim,

    Affiliation: Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

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  • Yuh-Min Chen,

    Affiliations: Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, School of Medicine, National Yang-Ming University, Taipei, Taiwan

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  • Hongxia Ma,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Min Shen,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Sung Ick Cha,

    Affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

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  • Wen Tan,

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

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  • Chin-Hao Chang,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Jae Sook Sung,

    Affiliations: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain, Korea University College of Medicine, Seoul, Republic of Korea

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  • Mingfeng Zhang,

    Affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

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  • Tsung-Ying Yang,

    Affiliation: Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

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  • Kyong Hwa Park,

    Affiliations: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea

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  • Jeff Yuenger,

    Affiliations: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America

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  • Chih-Liang Wang,

    Affiliation: Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taiwan

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  • Jeong-Seon Ryu,

    Affiliation: Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea

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  • Yongbing Xiang,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Qifei Deng,

    Affiliation: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China

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  • Amy Hutchinson,

    Affiliations: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America

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  • Jun Suk Kim,

    Affiliations: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain, Korea University College of Medicine, Seoul, Republic of Korea, Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea

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  • Qiuyin Cai,

    Affiliation: Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Maria Teresa Landi,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Chong-Jen Yu,

    Affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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  • Ju-Yeon Park,

    Affiliation: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

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  • Margaret Tucker,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Jen-Yu Hung,

    Affiliation: Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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  • Chien-Chung Lin,

    Affiliation: Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan

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  • Reury-Perng Perng,

    Affiliation: Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan

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  • Paolo Boffetta,

    Affiliation: International Agency for Research on Cancer, Lyon, France

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  • Chih-Yi Chen,

    Affiliation: Cancer Center, China Medical University Hospital, Taipei, Taiwan

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  • Kun-Chieh Chen,

    Affiliation: Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

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  • Shi-Yi Yang,

    Affiliation: Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan

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  • Chi-Yuan Hu,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Chung-Kai Chang,

    Affiliation: Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan

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  • Joseph F. Fraumeni Jr,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Stephen Chanock ,

    Affiliations: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America, Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America, Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

    These authors were joint senior authors on this work.

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  • Pan-Chyr Yang ,

    Affiliation: Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

    These authors were joint senior authors on this work.

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  • Nathaniel Rothman ,

    Affiliation: Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

    These authors were joint senior authors on this work.

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  • Dongxin Lin

    Affiliation: Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

    These authors were joint senior authors on this work.

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  • Published: August 05, 2010
  • DOI: 10.1371/journal.pgen.1001051

About the Authors

Chao Agnes Hsiung, Chin-Fu Hsiao, Wen-Chang Wang, Yen-Li Lo, Chin-Hao Chang, Chi-Yuan Hu, Chung-Kai Chang
Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
Qing Lan, H. Dean Hosgood III, Nilanjan Chatterjee, Meredith Yeager, Wong-Ho Chow, Neil Caporaso, Min Shen, Jeff Yuenger, Amy Hutchinson, Maria Teresa Landi, Margaret Tucker, Joseph F. Fraumeni Jr, Stephen Chanock, Nathaniel Rothman
Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
Yun-Chul Hong, Kyoung-Mu Lee, Jin Hee Kim
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Yun-Chul Hong, Jin Hee Kim
Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea
Chien-Jen Chen
Genomics Research Center, Academia Sinica, Taipei, Taiwan
Chien-Jen Chen, Shi-Yi Yang
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
I-Shou Chang
National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan
Paul Brennan, Paolo Boffetta
International Agency for Research on Cancer, Lyon, France
Chen Wu, Liming Huang, Dianke Yu, Wen Tan, Dongxin Lin
Departments of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
Wei Zheng, Xiao-Ou Shu, Qiuyin Cai
Department of Medicine, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Gee-Chen Chang, Tsung-Ying Yang, Kun-Chieh Chen
Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Gee-Chen Chang
Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan
Gee-Chen Chang
School of Medicine, China Medical University, Taichung, Taiwan
Tangchun Wu, Huan Guo, Li Liu, Ping Xu, Qifei Deng
Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China
Jae Yong Park, Tae Hoon Jung, Chang Ho Kim, Sung Ick Cha
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
Jae Yong Park, In-San Kim
Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
Jae Yong Park
Cancer Research Center, Kyungpook National University Hospital, Daegu, Republic of Korea
Yeul Hong Kim, Jae Sook Sung, Kyong Hwa Park, Jun Suk Kim
Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea
Yeul Hong Kim, Jae Sook Sung, Jun Suk Kim
Department of Internal Medicine and Division of Brain, Korea University College of Medicine, Seoul, Republic of Korea
Yeul Hong Kim, Kyong Hwa Park, Jun Suk Kim
Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea
Hongbing Shen, Zhibin Hu, Guangfu Jin, Hongxia Ma, Mingfeng Zhang
Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China
Adeline Seow, Ying Chen
Department of Epidemiology and Public Health, National University of Singapore, Singapore, Singapore
Meredith Yeager, Jeff Yuenger, Amy Hutchinson, Stephen Chanock
Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Frederick, Maryland, United States of America
Ying-Huang Tsai, Chih-Liang Wang
Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taiwan
Ying-Huang Tsai
Department of Respiratory Care, Chang Gung University, Taiwan
Young Tae Kim, Ju-Yeon Park
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
Young Tae Kim, Joo Hyun Kim
Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
Sook Whan Sung
Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea
Sook Whan Sung
Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Geongi-do, Republic of Korea
Kuan-Yu Chen, Chong-Jen Yu, Pan-Chyr Yang
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Yu-Tang Gao, Yongbing Xiang
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Ming-Shyan Huang, Jen-Yu Hung
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Wu-Chou Su, Chien-Chung Lin
Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan
Yuh-Min Chen, Reury-Perng Perng
Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan
Yuh-Min Chen
School of Medicine, National Yang-Ming University, Taipei, Taiwan
Jeong-Seon Ryu
Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea
Chih-Yi Chen
Cancer Center, China Medical University Hospital, Taipei, Taiwan
Stephen Chanock
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CAH QL CJC ISC NC JYP YHK AS YTK JHK ISK JFFJ SJC PCY NR DL. Performed the experiments: CAH YCH CW TW HS MY YC JHK JSS JY AH SYY CYH SJC DL. Analyzed the data: CAH QL HDHI ISC NC CFH MY WCW YLL CHC JSS CKC SJC NR. Contributed reagents/materials/analysis tools: CAH QL YCH CJC HDHI NC PB CW WZ GCC TW YHK HS MY YHT YTK WHC HG SWS ZH KYC JHK LH KML YTG LL MSH THJ GJ NC DY CHK WCS XOS PX YMC HM MS SIC WT MZ TYY KHP JY CLW JSR YX QD AH JSK QC MTL CJY JYP MT JYH CCL RPP PB CYC KCC JFFJ SJC PCY NR DL. Wrote the paper: CAH QL YCH ISC. Manuscript revision: YCH DH CN PB AS MY WHC YTG NEC XOS MS JY AH QC MT JF SJC NR.