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Research Article

Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

  • Magda Granata equal contributor,

    equal contributor Contributed equally to this work with: Magda Granata, Federico Lazzaro

    Affiliation: Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy

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  • Federico Lazzaro equal contributor,

    equal contributor Contributed equally to this work with: Magda Granata, Federico Lazzaro

    Affiliation: Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy

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  • Daniele Novarina,

    Affiliation: Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy

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  • Davide Panigada,

    Affiliation: Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy

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  • Fabio Puddu,

    Affiliation: Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy

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  • Carla Manuela Abreu,

    Affiliation: Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland

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  • Ramesh Kumar,

    Affiliation: Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland

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  • Muriel Grenon,

    Affiliation: Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland

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  • Noel F. Lowndes,

    Affiliation: Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland

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  • Paolo Plevani mail,

    marco.muzifalconi@unimi.it (MM-F); paolo.plevani@unimi.it (PP)

    Affiliation: Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy

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  • Marco Muzi-Falconi mail

    marco.muzifalconi@unimi.it (MM-F); paolo.plevani@unimi.it (PP)

    Affiliation: Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy

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  • Published: August 05, 2010
  • DOI: 10.1371/journal.pgen.1001047

About the Authors

Magda Granata, Federico Lazzaro, Daniele Novarina, Davide Panigada, Fabio Puddu, Paolo Plevani, Marco Muzi-Falconi
Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy
Carla Manuela Abreu, Ramesh Kumar, Muriel Grenon, Noel F. Lowndes
Centre for Chromosome Biology, School of Natural Science, National University of Ireland Galway, Galway, Ireland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M Granata, F Lazzaro, R Kumar, M Grenon, NF Lowndes, P Plevani, M Muzi-Falconi. Performed the experiments: M Granata, F Lazzaro, D Novarina, D Panigada, F Puddu, CM Abreu. Analyzed the data: M Granata, F Lazzaro, D Novarina, D Panigada, F Puddu, M Grenon, NF Lowndes, P Plevani, M Muzi-Fal. Contributed reagents/materials/analysis tools: M Granata, F Lazzaro, D Novarina, D Panigada, F Puddu. Wrote the paper: NF Lowndes, P Plevani, M Muzi-Falconi.