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Research Article

Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake

  • Brock C. Christensen,

    Affiliations: Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America, Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America

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  • Karl T. Kelsey,

    Affiliations: Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America, Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America

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  • Shichun Zheng,

    Affiliation: Department of Neurological Surgery, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • E. Andres Houseman,

    Affiliations: Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Carmen J. Marsit,

    Affiliations: Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America, Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America

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  • Margaret R. Wrensch,

    Affiliation: Department of Neurological Surgery, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Joseph L. Wiemels,

    Affiliation: Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

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  • Heather H. Nelson,

    Affiliation: Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Margaret R. Karagas,

    Affiliation: Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, United States of America

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  • Lawrence H. Kushi,

    Affiliation: Division of Research, Kaiser Permanente, Oakland, California, United States of America

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  • Marilyn L. Kwan,

    Affiliation: Division of Research, Kaiser Permanente, Oakland, California, United States of America

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  • John K. Wiencke mail

    John.Wiencke@UCSF.edu

    Affiliation: Department of Neurological Surgery, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Published: July 29, 2010
  • DOI: 10.1371/journal.pgen.1001043

About the Authors

Brock C. Christensen, Karl T. Kelsey, Carmen J. Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman, Carmen J. Marsit
Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America
Shichun Zheng, Margaret R. Wrensch, John K. Wiencke
Department of Neurological Surgery, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California, United States of America
E. Andres Houseman
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Joseph L. Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
Heather H. Nelson
Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America
Margaret R. Karagas
Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
Lawrence H. Kushi, Marilyn L. Kwan
Division of Research, Kaiser Permanente, Oakland, California, United States of America

Corresponding Author

Email: John.Wiencke@UCSF.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BCC KTK CJM MRW JLW HHN MRK LHK MLK JKW. Performed the experiments: BCC SZ. Analyzed the data: BCC SZ EAH CJM. Contributed reagents/materials/analysis tools: KTK EAH LHK MLK JKW. Wrote the paper: BCC KTK CJM MRW JLW HHN MRK LHK MLK JKW.