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Research Article

Inter- and Intra-Individual Variation in Allele-Specific DNA Methylation and Gene Expression in Children Conceived using Assisted Reproductive Technology

  • Nahid Turan,

    Affiliation: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Sunita Katari,

    Affiliation: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Leigh F. Gerson,

    Affiliation: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Raffi Chalian,

    Affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Michael W. Foster,

    Affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • John P. Gaughan,

    Affiliation: Biostatistics Consulting Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Christos Coutifaris,

    Affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Carmen Sapienza mail

    sapienza@temple.edu

    Affiliations: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: July 22, 2010
  • DOI: 10.1371/journal.pgen.1001033

About the Authors

Nahid Turan, Sunita Katari, Leigh F. Gerson, Carmen Sapienza
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
Raffi Chalian, Michael W. Foster, Christos Coutifaris
Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
John P. Gaughan
Biostatistics Consulting Center, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
Carmen Sapienza
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: sapienza@temple.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NT SK RC CC CS. Performed the experiments: NT SK LFG. Analyzed the data: NT SK JPG CC CS. Contributed reagents/materials/analysis tools: NT SK RC MWF JPG. Wrote the paper: NT SK CC CS.