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Research Article

Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility

  • Yen Ling Low equal contributor,

    equal contributor Contributed equally to this work with: Yen Ling Low, Yuqing Li, Keith Humphreys

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

    X
  • Yuqing Li equal contributor,

    equal contributor Contributed equally to this work with: Yen Ling Low, Yuqing Li, Keith Humphreys

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

    X
  • Keith Humphreys equal contributor,

    equal contributor Contributed equally to this work with: Yen Ling Low, Yuqing Li, Keith Humphreys

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    X
  • Anbupalam Thalamuthu,

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Yi Li,

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Hatef Darabi,

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Sara Wedrén,

    Affiliation: Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

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  • Carine Bonnard,

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Kamila Czene,

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Mark M. Iles,

    Affiliation: Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom

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  • Tuomas Heikkinen,

    Affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

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  • Kristiina Aittomäki,

    Affiliation: Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland

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  • Carl Blomqvist,

    Affiliations: Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland, Department of Oncology, Radiology, and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden

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  • Heli Nevanlinna,

    Affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

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  • Per Hall mail,

    liuj3@gis.a-star.edu.sg (JL); liue@gis.a-star.edu.sg (ETL); Per.Hall@ki.se (PH)

    Affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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  • Edison T. Liu mail,

    liuj3@gis.a-star.edu.sg (JL); liue@gis.a-star.edu.sg (ETL); Per.Hall@ki.se (PH)

    Affiliation: Cancer Biology, Genome Institute of Singapore, Singapore, Singapore

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  • Jianjun Liu mail

    liuj3@gis.a-star.edu.sg (JL); liue@gis.a-star.edu.sg (ETL); Per.Hall@ki.se (PH)

    Affiliation: Human Genetics, Genome Institute of Singapore, Singapore, Singapore

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  • Published: July 01, 2010
  • DOI: 10.1371/journal.pgen.1001012

About the Authors

Yen Ling Low, Yuqing Li, Anbupalam Thalamuthu, Yi Li, Carine Bonnard, Jianjun Liu
Human Genetics, Genome Institute of Singapore, Singapore, Singapore
Keith Humphreys, Hatef Darabi, Kamila Czene, Per Hall
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Sara Wedrén
Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Mark M. Iles
Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom
Tuomas Heikkinen, Heli Nevanlinna
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Kristiina Aittomäki
Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland
Carl Blomqvist
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Carl Blomqvist
Department of Oncology, Radiology, and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden
Edison T. Liu
Cancer Biology, Genome Institute of Singapore, Singapore, Singapore

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: Keith Humphreys, Sara Wedrén, Heli Nevanlinna, Per Hall, Edison T. Liu, Jianjun Liu. Performed the experiments: Yuqing Li, Carine Bonnard. Analyzed the data: Yuqing Li, Keith Humphreys, Anbupalam Thalamuthu, Yi Li, Hatef Darabi, Mark M. Iles. Contributed reagents/materials/analysis tools: Sara Wedrén, Tuomas Heikkinen, Kristiina Aittomäki, Carl Blomqvist. Wrote the paper: Yen Ling Low, Keith Humphreys, Kamila Czene, Per Hall, Edison T. Liu, Jianjun Liu.