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Research Article

Comparative Analysis of DNA Replication Timing Reveals Conserved Large-Scale Chromosomal Architecture

  • Eitan Yaffe equal contributor,

    equal contributor Contributed equally to this work with: Eitan Yaffe, Shlomit Farkash-Amar

    Affiliation: Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

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  • Shlomit Farkash-Amar equal contributor,

    equal contributor Contributed equally to this work with: Eitan Yaffe, Shlomit Farkash-Amar

    Affiliation: Department of Microbiology and Molecular Genetics, the Institute for Medical Research – Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel

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  • Andreas Polten,

    Affiliation: Agilent Technologies, Waldbronn, Germany

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  • Zohar Yakhini,

    Affiliations: Department of Computer Sciences, Technion – Israel Institute of Technology, Haifa, Israel, Agilent Laboratories, Tel-Aviv, Israel

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  • Amos Tanay mail,

    amos.tanay@weizmann.ac.il (AT); itamarsi@ekmd.huji.ac.il (IS)

    Affiliation: Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel

    X
  • Itamar Simon mail

    amos.tanay@weizmann.ac.il (AT); itamarsi@ekmd.huji.ac.il (IS)

    Affiliation: Department of Microbiology and Molecular Genetics, the Institute for Medical Research – Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel

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  • Published: July 01, 2010
  • DOI: 10.1371/journal.pgen.1001011

About the Authors

Eitan Yaffe, Amos Tanay
Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel
Shlomit Farkash-Amar, Itamar Simon
Department of Microbiology and Molecular Genetics, the Institute for Medical Research – Israel-Canada, the Hebrew University-Hadassah Medical School, Jerusalem, Israel
Andreas Polten
Agilent Technologies, Waldbronn, Germany
Zohar Yakhini
Department of Computer Sciences, Technion – Israel Institute of Technology, Haifa, Israel
Zohar Yakhini
Agilent Laboratories, Tel-Aviv, Israel

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SFA IS. Performed the experiments: SFA. Analyzed the data: EY SFA AT IS. Contributed reagents/materials/analysis tools: AP ZY. Wrote the paper: EY SFA AT IS.