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Research Article

Identification of a Functional Genetic Variant at 16q12.1 for Breast Cancer Risk: Results from the Asia Breast Cancer Consortium

  • Jirong Long,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Qiuyin Cai,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Xiao-Ou Shu,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Shimian Qu,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Chun Li,

    Affiliation: Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Ying Zheng,

    Affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China

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  • Kai Gu,

    Affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China

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  • Wenjing Wang,

    Affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China

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  • Yong-Bing Xiang,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Jiarong Cheng,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Kexin Chen,

    Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

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  • Lina Zhang,

    Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

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  • Hong Zheng,

    Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

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  • Chen-Yang Shen,

    Affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

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  • Chiun-Sheng Huang,

    Affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

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  • Ming-Feng Hou,

    Affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

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  • Hongbing Shen,

    Affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China

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  • Zhibin Hu,

    Affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China

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  • Furu Wang,

    Affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China

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  • Sandra L. Deming,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Mark C. Kelley,

    Affiliation: Division of Surgical Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Martha J. Shrubsole,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Ui Soon Khoo,

    Affiliation: Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China

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  • Kelvin Y. K. Chan,

    Affiliation: Division of Surgical Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Sum Yin Chan,

    Affiliation: Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China

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  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

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  • Brian E. Henderson,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

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  • Loic Le Marchand,

    Affiliation: Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America

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  • Motoki Iwasaki,

    Affiliation: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

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  • Yoshio Kasuga,

    Affiliation: Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan

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  • Shoichiro Tsugane,

    Affiliation: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

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  • Keitaro Matsuo,

    Affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

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  • Kazuo Tajima,

    Affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

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  • Hiroji Iwata,

    Affiliation: Department of Breast Oncology, Aichi Cancer Center Central Hospital, Nagoya, Japan

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  • Bo Huang,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Jiajun Shi,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Guoliang Li,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Wanqing Wen,

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Yu-Tang Gao,

    Affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

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  • Wei Lu,

    Affiliation: Shanghai Center for Disease Control and Prevention, Shanghai, China

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  • Wei Zheng mail

    wei.zheng@vanderbilt.edu

    Affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Published: June 24, 2010
  • DOI: 10.1371/journal.pgen.1001002

About the Authors

Jirong Long, Qiuyin Cai, Xiao-Ou Shu, Shimian Qu, Sandra L. Deming, Martha J. Shrubsole, Bo Huang, Jiajun Shi, Guoliang Li, Wanqing Wen, Wei Zheng
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Chun Li
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Ying Zheng, Kai Gu, Wenjing Wang, Wei Lu
Shanghai Center for Disease Control and Prevention, Shanghai, China
Yong-Bing Xiang, Jiarong Cheng, Yu-Tang Gao
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Kexin Chen, Lina Zhang, Hong Zheng
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Chen-Yang Shen, Chiun-Sheng Huang, Ming-Feng Hou
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Hongbing Shen, Zhibin Hu, Furu Wang
Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China
Mark C. Kelley, Kelvin Y. K. Chan
Division of Surgical Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Ui Soon Khoo, Sum Yin Chan
Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
Christopher A. Haiman, Brian E. Henderson
Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Loic Le Marchand
Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America
Motoki Iwasaki, Shoichiro Tsugane
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
Yoshio Kasuga
Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan
Keitaro Matsuo, Kazuo Tajima
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Hiroji Iwata
Department of Breast Oncology, Aichi Cancer Center Central Hospital, Nagoya, Japan

Corresponding Author

Email: wei.zheng@vanderbilt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: W Zheng. Performed the experiments: Q Cai, S Qul, B Huang. Wrote the paper: J Long, Q Cai, XO Shu, S Qul, W Zheng. Designed and directed the study: W Zheng. Drafted the manuscript: J Long, W Zheng, Q Cai, XO Shu, S Qul. Directed the studies that contributed data to consortium or contributed to data and biological collection of these original studies: XO Shu, Y Zheng, K Gu, W Wang, YB Xiang, J Cheng, K Chen, L Zhang, H Zheng, CY Shen, CS Huang, MF Hou, H Shen, Z Hu, F Wang, SL Deming, MC Kelley, MJ Shrubsole, US Khoo, KYK Chan, SY Chan, CA Haiman, BE Henderson, L Le Marchand, M Iwasaki, Y Kasuga, S Tsugane, K Matsuo, K Tajima, H Iwata, YT Gao, W Lu, W Zheng. Coordinated the genetic study: J Long. Managed the genotyping data: J Long. Performed statistical analyses: J Long, C Li, W Wen. Directed lab operations: Q Cai. Conducted in vitro functional experiments: Q Cai, S Qul, B Huang. Performed genotyping assays: J Shi, G Li.