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Research Article

Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits

  • Nicholas Eriksson mail,

    nick@23andme.com (NE); joanna@23andme.com (JM)

    Affiliation: 23andMe, Mountain View, California, United States of America

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  • J. Michael Macpherson,

    Affiliation: 23andMe, Mountain View, California, United States of America

    X
  • Joyce Y. Tung,

    Affiliation: 23andMe, Mountain View, California, United States of America

    X
  • Lawrence S. Hon,

    Affiliation: 23andMe, Mountain View, California, United States of America

    X
  • Brian Naughton,

    Affiliation: 23andMe, Mountain View, California, United States of America

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  • Serge Saxonov,

    Affiliation: 23andMe, Mountain View, California, United States of America

    X
  • Linda Avey,

    Affiliation: 23andMe, Mountain View, California, United States of America

    X
  • Anne Wojcicki,

    Affiliation: 23andMe, Mountain View, California, United States of America

    X
  • Itsik Pe'er,

    Affiliation: Department of Computer Science, Columbia University, New York, New York, United States of America

    X
  • Joanna Mountain mail

    nick@23andme.com (NE); joanna@23andme.com (JM)

    Affiliations: 23andMe, Mountain View, California, United States of America, Department of Anthropology, Stanford University, Stanford, California, United States of America

    X
  • Published: June 24, 2010
  • DOI: 10.1371/journal.pgen.1000993

About the Authors

Nicholas Eriksson, J. Michael Macpherson, Joyce Y. Tung, Lawrence S. Hon, Brian Naughton, Serge Saxonov, Linda Avey, Anne Wojcicki, Joanna Mountain
23andMe, Mountain View, California, United States of America
Itsik Pe'er
Department of Computer Science, Columbia University, New York, New York, United States of America
Joanna Mountain
Department of Anthropology, Stanford University, Stanford, California, United States of America

Corresponding Authors

Competing Interests

NE, JMM, JYT, LSH, BN, SS, LA, AW, and JM are or have been employed by 23andMe and own stock options in the company. 23andMe co-president AW has provided general guidance, including guidance related to the company's research undertakings and direction. PLoS Genetics' Editor-in-Chief Gregory S. Barsh is a potential consultant to 23andMe and therefore recused himself from the editorial and peer-review process. PLoS co-founder Michael B. Eisen is a member of the 23andMe Scientific Advisory Board.

Author Contributions

Conceived and designed the experiments: NE JMM JYT LSH BN SS LA AW IP JM. Performed the experiments: NE JMM JYT LSH BN SS LA AW IP JM. Analyzed the data: NE JMM JYT. Contributed reagents/materials/analysis tools: NE JMM LSH JM. Wrote the paper: NE JMM JYT LSH BN SS IP JM.