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Research Article

The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2: Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers

  • Masayo Kagami,

    Affiliation: Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Maureen J. O'Sullivan,

    Affiliation: Department of Pathology, School of Medicine, Our Lady's Children's Hospital, Trinity College, Dublin, Ireland

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  • Andrew J. Green,

    Affiliations: National Center for Medical Genetics, University College Dublin, Our Lady's Hospital, Dublin, Ireland, School of Medicine and Medical Science, University College, Dublin, Ireland

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  • Yoshiyuki Watabe,

    Affiliation: Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan

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  • Osamu Arisaka,

    Affiliation: Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan

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  • Nobuhide Masawa,

    Affiliation: Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan

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  • Kentarou Matsuoka,

    Affiliation: Department of Pathology, National Center for Child Health and Development, Tokyo, Japan

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  • Maki Fukami,

    Affiliation: Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Keiko Matsubara,

    Affiliation: Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Fumiko Kato,

    Affiliation: Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Anne C. Ferguson-Smith,

    Affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

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  • Tsutomu Ogata mail

    tomogata@nch.go.jp

    Affiliation: Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan

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  • Published: June 17, 2010
  • DOI: 10.1371/journal.pgen.1000992
  • Featured in PLOS Collections

About the Authors

Masayo Kagami, Maki Fukami, Keiko Matsubara, Fumiko Kato, Tsutomu Ogata
Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
Maureen J. O'Sullivan
Department of Pathology, School of Medicine, Our Lady's Children's Hospital, Trinity College, Dublin, Ireland
Andrew J. Green
National Center for Medical Genetics, University College Dublin, Our Lady's Hospital, Dublin, Ireland
Andrew J. Green
School of Medicine and Medical Science, University College, Dublin, Ireland
Yoshiyuki Watabe, Osamu Arisaka
Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan
Nobuhide Masawa
Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan
Kentarou Matsuoka
Department of Pathology, National Center for Child Health and Development, Tokyo, Japan
Anne C. Ferguson-Smith
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: tomogata@nch.go.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK ACFS TO. Performed the experiments: MK MF KM FK. Analyzed the data: MK TO. Contributed reagents/materials/analysis tools: MJO AJG YW OA NM KM TO. Wrote the paper: TO.