Advertisement
Research Article

Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling

  • Lutz Kockel mail,

    perrimon@receptor.med.harvard.edu (NP); lutz.kockel@ucsf.edu (LK)

    Affiliations: Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Kimberly S. Kerr,

    Affiliation: Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    Current address: University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    X
  • Michael Melnick,

    Affiliation: Cell Signaling Technology, Beverley, Massachusetts, United States of America

    Current address: CMEA Ventures, San Francisco, California, United States of America

    X
  • Katja Brückner,

    Affiliation: Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, California, United States of America

    X
  • Matthias Hebrok,

    Affiliation: Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Norbert Perrimon mail

    perrimon@receptor.med.harvard.edu (NP); lutz.kockel@ucsf.edu (LK)

    Affiliation: Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: June 17, 2010
  • DOI: 10.1371/journal.pgen.1000990

About the Authors

Lutz Kockel, Norbert Perrimon
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Lutz Kockel, Kimberly S. Kerr, Matthias Hebrok
Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Michael Melnick
Cell Signaling Technology, Beverley, Massachusetts, United States of America
Katja Brückner
Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LK MH NP. Performed the experiments: LK KSK KB. Analyzed the data: LK KSK KB MH NP. Contributed reagents/materials/analysis tools: LK KSK MM KB. Wrote the paper: LK KB MH NP.