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Research Article

The CFTR Met 470 Allele Is Associated with Lower Birth Rates in Fertile Men from a Population Isolate

  • Gülüm Kosova mail,

    gulum@uchicago.edu

    Affiliations: Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Joseph K. Pickrell,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Joanna L. Kelley,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Patrick F. McArdle,

    Affiliation: Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Alan R. Shuldiner,

    Affiliations: Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Geriatrics Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America

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  • Mark Abney,

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Carole Ober

    Affiliations: Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, United States of America

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  • Published: June 03, 2010
  • DOI: 10.1371/journal.pgen.1000974

About the Authors

Gülüm Kosova, Carole Ober
Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois, United States of America
Gülüm Kosova, Joseph K. Pickrell, Joanna L. Kelley, Mark Abney, Carole Ober
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
Patrick F. McArdle, Alan R. Shuldiner
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Alan R. Shuldiner
Geriatrics Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, United States of America
Carole Ober
Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: gulum@uchicago.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GK CO. Performed the experiments: GK PFM. Analyzed the data: GK PFM. Contributed reagents/materials/analysis tools: MA. Wrote the paper: GK CO. Data interpretation: JKP JLK MA. Critical review of the manuscript: JKP JLK MA. Performed and analyzed the data in the Amish population: PFM. Provided the data for the replication studies in the Amish population: ARS. Data collection: CO. Project supervision: CO.