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Research Article

Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin

  • Elke Grönniger,

    Affiliation: Research and Development, Beiersdorf AG, Hamburg, Germany

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  • Barbara Weber,

    Affiliation: Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany

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  • Oliver Heil,

    Affiliation: Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany

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  • Nils Peters,

    Affiliation: Research and Development, Beiersdorf AG, Hamburg, Germany

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  • Franz Stäb,

    Affiliation: Research and Development, Beiersdorf AG, Hamburg, Germany

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  • Horst Wenck,

    Affiliation: Research and Development, Beiersdorf AG, Hamburg, Germany

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  • Bernhard Korn,

    Affiliation: Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany

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  • Marc Winnefeld,

    Affiliation: Research and Development, Beiersdorf AG, Hamburg, Germany

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  • Frank Lyko mail

    f.lyko@dkfz.de

    Affiliation: Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany

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  • Published: May 27, 2010
  • DOI: 10.1371/journal.pgen.1000971

About the Authors

Elke Grönniger, Nils Peters, Franz Stäb, Horst Wenck, Marc Winnefeld
Research and Development, Beiersdorf AG, Hamburg, Germany
Barbara Weber, Frank Lyko
Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
Oliver Heil, Bernhard Korn
Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany

Corresponding Author

Email: f.lyko@dkfz.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EG BW MW FL. Performed the experiments: EG BW. Analyzed the data: EG BW OH MW FL. Contributed reagents/materials/analysis tools: NP BK. Wrote the paper: MW FL. Assisted in study conception and design and interpretation of results: FS HW.