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Research Article

Caenorhabditis elegans SMA-10/LRIG Is a Conserved Transmembrane Protein that Enhances Bone Morphogenetic Protein Signaling

  • Tina L. Gumienny,

    Affiliation: Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, United States of America

    Current address: Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, Texas, United States of America

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  • Lesley MacNeil,

    Affiliations: Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Canada

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  • Cole M. Zimmerman,

    Affiliation: Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, United States of America

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  • Huang Wang,

    Affiliation: Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, United States of America

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  • Lena Chin,

    Affiliation: Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, United States of America

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  • Jeffrey L. Wrana,

    Affiliations: Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Canada

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  • Richard W. Padgett mail

    padgett@waksman.rutgers.edu

    Affiliation: Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, United States of America

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  • Published: May 20, 2010
  • DOI: 10.1371/journal.pgen.1000963

About the Authors

Tina L. Gumienny, Cole M. Zimmerman, Huang Wang, Lena Chin, Richard W. Padgett
Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, United States of America
Lesley MacNeil, Jeffrey L. Wrana
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Lesley MacNeil, Jeffrey L. Wrana
Department of Molecular and Medical Genetics, University of Toronto, Toronto, Canada

Corresponding Author

Email: padgett@waksman.rutgers.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TLG LM CMZ HW LC JLW RWP. Performed the experiments: TLG LM CMZ HW LC. Analyzed the data: TLG LM CMZ HW LC JLW RWP. Contributed reagents/materials/analysis tools: JLW. Wrote the paper: TLG RWP.