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Research Article

Activation of Estrogen-Responsive Genes Does Not Require Their Nuclear Co-Localization

  • Silvia Kocanova equal contributor,

    equal contributor Contributed equally to this work with: Silvia Kocanova, Elizabeth A. Kerr

    Affiliations: Laboratoire de Biologie Moléculaire Eucaryote, Université de Toulouse - UPS, Toulouse, France, LBME, CNRS, Toulouse, France

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  • Elizabeth A. Kerr equal contributor,

    equal contributor Contributed equally to this work with: Silvia Kocanova, Elizabeth A. Kerr

    Affiliations: The Breakthrough Breast Cancer Research Unit, Edinburgh, United Kingdom, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Sehrish Rafique,

    Affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Shelagh Boyle,

    Affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Elad Katz,

    Affiliation: The Breakthrough Breast Cancer Research Unit, Edinburgh, United Kingdom

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  • Stephanie Caze-Subra,

    Affiliations: Laboratoire de Biologie Moléculaire Eucaryote, Université de Toulouse - UPS, Toulouse, France, LBME, CNRS, Toulouse, France

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  • Wendy A. Bickmore mail,

    W.Bickmore@hgu.mrc.ac.uk (WAB); kerstin.bystricky@biotoul.fr (KB)

    Affiliation: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Kerstin Bystricky mail

    W.Bickmore@hgu.mrc.ac.uk (WAB); kerstin.bystricky@biotoul.fr (KB)

    Affiliations: Laboratoire de Biologie Moléculaire Eucaryote, Université de Toulouse - UPS, Toulouse, France, LBME, CNRS, Toulouse, France

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  • Published: April 22, 2010
  • DOI: 10.1371/journal.pgen.1000922

About the Authors

Silvia Kocanova, Stephanie Caze-Subra, Kerstin Bystricky
Laboratoire de Biologie Moléculaire Eucaryote, Université de Toulouse - UPS, Toulouse, France
Silvia Kocanova, Stephanie Caze-Subra, Kerstin Bystricky
LBME, CNRS, Toulouse, France
Elizabeth A. Kerr, Elad Katz
The Breakthrough Breast Cancer Research Unit, Edinburgh, United Kingdom
Elizabeth A. Kerr, Sehrish Rafique, Shelagh Boyle, Wendy A. Bickmore
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WAB KB. Performed the experiments: SK EAK SR SB EK SCS. Analyzed the data: SK EAK WAB KB. Wrote the paper: SK EAK WAB KB.