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Research Article

Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells

  • Yuping Luo equal contributor,

    equal contributor Contributed equally to this work with: Yuping Luo, Ge Shan, Weixiang Guo

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Ge Shan equal contributor,

    equal contributor Contributed equally to this work with: Yuping Luo, Ge Shan, Weixiang Guo

    Affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

    Current address: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China

    X
  • Weixiang Guo equal contributor,

    equal contributor Contributed equally to this work with: Yuping Luo, Ge Shan, Weixiang Guo

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

    X
  • Richard D. Smrt ,

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

    These authors also contributed equally to this work.

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  • Eric B. Johnson ,

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

    These authors also contributed equally to this work.

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  • Xuekun Li,

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Rebecca L. Pfeiffer,

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Keith E. Szulwach,

    Affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Ranhui Duan,

    Affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Basam Z. Barkho,

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Wendi Li,

    Affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Changmei Liu,

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

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  • Peng Jin mail,

    xzhao@salud.unm.edu (XZ); peng.jin@emory.edu (PJ)

    Affiliation: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

    X
  • Xinyu Zhao mail

    xzhao@salud.unm.edu (XZ); peng.jin@emory.edu (PJ)

    Affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America

    X
  • Published: April 08, 2010
  • DOI: 10.1371/journal.pgen.1000898

About the Authors

Yuping Luo, Weixiang Guo, Richard D. Smrt, Eric B. Johnson, Xuekun Li, Rebecca L. Pfeiffer, Basam Z. Barkho, Changmei Liu, Xinyu Zhao
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America
Ge Shan, Keith E. Szulwach, Ranhui Duan, Wendi Li, Peng Jin
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YL GS WG PJ XZ. Performed the experiments: YL GS WG RDS EBJ XL RLP KES RD BZB WL CL PJ XZ. Analyzed the data: YL GS WG RDS EBJ XL RLP KES RD BZB WL CL PJ XZ. Contributed reagents/materials/analysis tools: PJ XZ. Wrote the paper: YL GS WG PJ XZ.