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Research Article

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

  • Dan L. Nicolae,

    Affiliations: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Department of Statistics, University of Chicago, Chicago, Illinois, United States of America

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  • Eric Gamazon,

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Wei Zhang,

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Shiwei Duan,

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

    Current address: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore

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  • M. Eileen Dolan,

    Affiliations: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Nancy J. Cox mail

    ncox@bsd.uchicago.edu

    Affiliations: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America, Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Published: April 01, 2010
  • DOI: 10.1371/journal.pgen.1000888

About the Authors

Dan L. Nicolae, Eric Gamazon, Wei Zhang, Shiwei Duan, M. Eileen Dolan, Nancy J. Cox
Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
Dan L. Nicolae, M. Eileen Dolan, Nancy J. Cox
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
Dan L. Nicolae
Department of Statistics, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: ncox@bsd.uchicago.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DLN MED NJC. Performed the experiments: EG. Analyzed the data: DLN EG WZ SD NJC. Contributed reagents/materials/analysis tools: EG WZ SD MED. Wrote the paper: DLN EG MED NJC.