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Research Article

KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading

  • Anna C. Groner,

    Affiliations: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Frontiers-in-Genetics National Center of Competence in Research, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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  • Sylvain Meylan,

    Affiliations: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Frontiers-in-Genetics National Center of Competence in Research, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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  • Angela Ciuffi,

    Affiliation: Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland

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  • Nadine Zangger,

    Affiliations: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Frontiers-in-Genetics National Center of Competence in Research, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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  • Giovanna Ambrosini,

    Affiliations: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Nicolas Dénervaud,

    Affiliation: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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  • Philipp Bucher,

    Affiliations: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Didier Trono mail

    didier.trono@epfl.ch

    Affiliations: School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Frontiers-in-Genetics National Center of Competence in Research, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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  • Published: March 05, 2010
  • DOI: 10.1371/journal.pgen.1000869

About the Authors

Anna C. Groner, Sylvain Meylan, Nadine Zangger, Giovanna Ambrosini, Nicolas Dénervaud, Philipp Bucher, Didier Trono
School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Anna C. Groner, Sylvain Meylan, Nadine Zangger, Didier Trono
Frontiers-in-Genetics National Center of Competence in Research, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Angela Ciuffi
Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
Giovanna Ambrosini, Philipp Bucher
Swiss Institute of Bioinformatics, Lausanne, Switzerland

Corresponding Author

Email: didier.trono@epfl.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ACG SM DT. Performed the experiments: ACG SM. Analyzed the data: ACG SM AC NZ GA ND PB. Contributed reagents/materials/analysis tools: AC NZ GA ND PB. Wrote the paper: ACG DT.