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Research Article

Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair

  • Marco Saponaro,

    Affiliation: Institute of Molecular Oncology Foundation, The Italian Foundation for Cancer Research and Dipartimento di Scienze Biomolecolari e Biotecnologie–University of Milan, Milan, Italy

    Current address: London Research Institute, Clare Hall Laboratories, South Mimms, United Kingdom

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  • Devon Callahan,

    Affiliation: Department of Biochemistry and Kaplan Cancer Center, New York University School of Medicine, New York, New York, United States of America

    Current address: College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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  • Xiuzhong Zheng,

    Affiliation: Department of Biochemistry and Kaplan Cancer Center, New York University School of Medicine, New York, New York, United States of America

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  • Lumir Krejci,

    Affiliation: Department of Biology and National Center for Biomolecular Research, Masaryk University, Brno, Czech Republic

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  • James E. Haber,

    Affiliation: Department of Biology and Rosenstiel Medical Center, Brandeis University, Waltham, Massachusetts, United States of America

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  • Hannah L. Klein,

    Affiliation: Department of Biochemistry and Kaplan Cancer Center, New York University School of Medicine, New York, New York, United States of America

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  • Giordano Liberi mail

    giordano.liberi@ifom-ieo.campus.it

    Affiliation: Institute of Molecular Oncology Foundation, The Italian Foundation for Cancer Research and Dipartimento di Scienze Biomolecolari e Biotecnologie–University of Milan, Milan, Italy

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  • Published: February 26, 2010
  • DOI: 10.1371/journal.pgen.1000858

About the Authors

Marco Saponaro, Giordano Liberi
Institute of Molecular Oncology Foundation, The Italian Foundation for Cancer Research and Dipartimento di Scienze Biomolecolari e Biotecnologie–University of Milan, Milan, Italy
Devon Callahan, Xiuzhong Zheng, Hannah L. Klein
Department of Biochemistry and Kaplan Cancer Center, New York University School of Medicine, New York, New York, United States of America
Lumir Krejci
Department of Biology and National Center for Biomolecular Research, Masaryk University, Brno, Czech Republic
James E. Haber
Department of Biology and Rosenstiel Medical Center, Brandeis University, Waltham, Massachusetts, United States of America

Corresponding Author

Email: giordano.liberi@ifom-ieo.campus.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MS HK GL. Performed the experiments: MS GL. Analyzed the data: MS HK GL. Contributed reagents/materials/analysis tools: DC XZ LK JEH HK. Wrote the paper: MS GL.