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Research Article

Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

  • Demetris Pillas equal contributor,

    equal contributor Contributed equally to this work with: Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

    Affiliations: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom, Economic and Social Research Council International Centre for Life Course Studies in Society and Health, London, United Kingdom, Medical Research Council Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, United Kingdom

    X
  • Clive J. Hoggart equal contributor,

    equal contributor Contributed equally to this work with: Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

    Affiliation: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom

    X
  • David M. Evans equal contributor,

    equal contributor Contributed equally to this work with: Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

    Affiliation: Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

    X
  • Paul F. O'Reilly equal contributor,

    equal contributor Contributed equally to this work with: Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

    Affiliation: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom

    X
  • Kirsi Sipilä,

    Affiliations: Department of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Oulu, Oulu, Finland, Oral and Maxillofacial Department, Oulu University Hospital, Oulu, Finland

    X
  • Raija Lähdesmäki,

    Affiliations: Oral and Maxillofacial Department, Oulu University Hospital, Oulu, Finland, Department of Oral Development and Orthodontics, Institute of Dentistry, University of Oulu, Oulu, Finland

    X
  • Iona Y. Millwood,

    Affiliations: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom, Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom

    X
  • Marika Kaakinen,

    Affiliations: Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland

    X
  • Gopalakrishnan Netuveli,

    Affiliations: Economic and Social Research Council International Centre for Life Course Studies in Society and Health, London, United Kingdom, Department of Primary Care and Social Medicine, Faculty of Medicine, Imperial College London, United Kingdom

    X
  • David Blane,

    Affiliations: Economic and Social Research Council International Centre for Life Course Studies in Society and Health, London, United Kingdom, Department of Primary Care and Social Medicine, Faculty of Medicine, Imperial College London, United Kingdom

    X
  • Pimphen Charoen,

    Affiliations: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom, Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Ulla Sovio,

    Affiliation: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom

    X
  • Anneli Pouta,

    Affiliation: Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland

    X
  • Nelson Freimer,

    Affiliations: Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, Los Angeles, California, United States of America, Department of Psychiatry, University of California Los Angeles, Los Angeles, California, United States of America

    X
  • Anna-Liisa Hartikainen,

    Affiliation: Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland

    X
  • Jaana Laitinen,

    Affiliation: Finnish Institute of Occupational Health, Oulu, Finland

    X
  • Sarianna Vaara,

    Affiliation: Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland

    X
  • Beate Glaser,

    Affiliation: Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

    X
  • Peter Crawford,

    Affiliation: Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom

    X
  • Nicholas J. Timpson,

    Affiliation: Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

    X
  • Susan M. Ring,

    Affiliation: Avon Longitudinal Study of Parents and Children (ALSPAC), University of Bristol, Bristol, United Kingdom

    X
  • Guohong Deng,

    Affiliation: Department of Gastroenterology and Hepatology, Imperial College London, London, United Kingdom

    X
  • Weihua Zhang,

    Affiliation: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom

    X
  • Mark I. McCarthy,

    Affiliations: Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, United Kingdom

    X
  • Panos Deloukas,

    Affiliation: Wellcome Trust Sanger Institute, Welcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Leena Peltonen,

    Affiliations: Wellcome Trust Sanger Institute, Welcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Institute of Molecular Medicine Finland FIMM, Nordic EMBL Partnership for Molecular Medicine, Helsinki, Finland, Department of Medical Genetics, University of Helsinki, Helsinki, Finland, National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland

    X
  • Paul Elliott equal contributor,

    equal contributor Contributed equally to this work with: Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

    Affiliations: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom, Medical Research Council–Health Protection Agency Centre in Environment and Health, London, United Kingdom

    X
  • Lachlan J. M. Coin equal contributor,

    equal contributor Contributed equally to this work with: Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

    Affiliation: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom

    X
  • George Davey Smith equal contributor,

    equal contributor Contributed equally to this work with: Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

    Affiliation: Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom

    X
  • Marjo-Riitta Jarvelin equal contributor mail

    equal contributor Contributed equally to this work with: Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

    m.jarvelin@imperial.ac.uk

    Affiliations: Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland

    X
  • Published: February 26, 2010
  • DOI: 10.1371/journal.pgen.1000856

About the Authors

Demetris Pillas, Clive J. Hoggart, Paul F. O'Reilly, Iona Y. Millwood, Pimphen Charoen, Ulla Sovio, Weihua Zhang, Paul Elliott, Lachlan J. M. Coin, Marjo-Riitta Jarvelin
Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
Demetris Pillas, Gopalakrishnan Netuveli, David Blane
Economic and Social Research Council International Centre for Life Course Studies in Society and Health, London, United Kingdom
Demetris Pillas
Medical Research Council Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, United Kingdom
David M. Evans, Beate Glaser, Nicholas J. Timpson, George Davey Smith
Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Kirsi Sipilä
Department of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Oulu, Oulu, Finland
Kirsi Sipilä, Raija Lähdesmäki
Oral and Maxillofacial Department, Oulu University Hospital, Oulu, Finland
Raija Lähdesmäki
Department of Oral Development and Orthodontics, Institute of Dentistry, University of Oulu, Oulu, Finland
Iona Y. Millwood
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
Marika Kaakinen, Marjo-Riitta Jarvelin
Institute of Health Sciences, University of Oulu, Oulu, Finland
Marika Kaakinen, Marjo-Riitta Jarvelin
Biocenter Oulu, University of Oulu, Oulu, Finland
Gopalakrishnan Netuveli, David Blane
Department of Primary Care and Social Medicine, Faculty of Medicine, Imperial College London, United Kingdom
Pimphen Charoen
Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Anneli Pouta, Sarianna Vaara, Marjo-Riitta Jarvelin
Department of Lifecourse and Services, National Institute of Health and Welfare, Oulu, Finland
Nelson Freimer
Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America
Nelson Freimer
The Jane and Terry Semel Institute for Neuroscience and Human Behavior, Los Angeles, California, United States of America
Nelson Freimer
Department of Psychiatry, University of California Los Angeles, Los Angeles, California, United States of America
Anna-Liisa Hartikainen
Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Oulu, Finland
Jaana Laitinen
Finnish Institute of Occupational Health, Oulu, Finland
Peter Crawford
Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom
Susan M. Ring
Avon Longitudinal Study of Parents and Children (ALSPAC), University of Bristol, Bristol, United Kingdom
Guohong Deng
Department of Gastroenterology and Hepatology, Imperial College London, London, United Kingdom
Mark I. McCarthy
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom
Mark I. McCarthy
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, United Kingdom
Panos Deloukas, Leena Peltonen
Wellcome Trust Sanger Institute, Welcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
Leena Peltonen
Institute of Molecular Medicine Finland FIMM, Nordic EMBL Partnership for Molecular Medicine, Helsinki, Finland
Leena Peltonen
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Leena Peltonen
National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland
Paul Elliott
Medical Research Council–Health Protection Agency Centre in Environment and Health, London, United Kingdom

Corresponding Author

Email: m.jarvelin@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DP MRJ. Analyzed the data: DP CJH DME PC LJMC. Wrote the paper: DP CJH DME PFO KS RL IYM MK GN DB US AP NF ALH JL SV BG PC NJT SMR GD WZ MIM PD LP PE LJMC GDS MRJ.