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Research Article

A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes

  • Shiro Maeda mail,

    smaeda@src.riken.jp

    Affiliation: Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa, Japan

    X
  • Masa-aki Kobayashi,

    Affiliations: Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa, Japan, Discovery Research Laboratories, Shionogi & Co., Toyonaka, Osaka, Japan

    X
  • Shin-ichi Araki,

    Affiliation: Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan

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  • Tetsuya Babazono,

    Affiliation: The Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan

    X
  • Barry I. Freedman,

    Affiliation: Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Meredith A. Bostrom,

    Affiliation: Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

    X
  • Jessica N. Cooke,

    Affiliation: Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Masao Toyoda,

    Affiliation: Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan

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  • Tomoya Umezono,

    Affiliation: Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan

    X
  • Lise Tarnow,

    Affiliation: Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark

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  • Torben Hansen,

    Affiliations: Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark

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  • Peter Gaede,

    Affiliation: Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark

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  • Anders Jorsal,

    Affiliation: Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark

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  • Daniel P. K. Ng,

    Affiliation: Department of Epidemiology and Public Health, National University of Singapore, Singapore

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  • Minoru Ikeda,

    Affiliation: Developmental Research Laboratories, Shionogi & Co., Toyonaka, Osaka, Japan

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  • Toru Yanagimoto,

    Affiliation: Developmental Research Laboratories, Shionogi & Co., Toyonaka, Osaka, Japan

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  • Tatsuhiko Tsunoda,

    Affiliation: Laboratory for Medical Informatics, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa, Japan

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  • Hiroyuki Unoki,

    Affiliation: Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa, Japan

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  • Koichi Kawai,

    Affiliation: Kawai Clinic, Tsukuba, Ibaraki, Japan

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  • Masahito Imanishi,

    Affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan

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  • Daisuke Suzuki,

    Affiliation: Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan

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  • Hyoung Doo Shin,

    Affiliation: Department of Life Science, Sogang University, Seoul, Korea

    X
  • Kyong Soo Park,

    Affiliations: Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea

    X
  • Atsunori Kashiwagi,

    Affiliation: Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan

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  • Yasuhiko Iwamoto,

    Affiliation: The Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan

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  • Kohei Kaku,

    Affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan

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  • Ryuzo Kawamori,

    Affiliation: Department of Medicine, Metabolism, and Endocrinology, School of Medicine, Juntendo University, Tokyo, Japan

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  • Hans-Henrik Parving,

    Affiliations: Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark, Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark

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  • Donald W. Bowden,

    Affiliation: Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Oluf Pedersen,

    Affiliations: Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark, Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark, Institute of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Yusuke Nakamura

    Affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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  • Published: February 12, 2010
  • DOI: 10.1371/journal.pgen.1000842

About the Authors

Shiro Maeda, Masa-aki Kobayashi, Hiroyuki Unoki
Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa, Japan
Masa-aki Kobayashi
Discovery Research Laboratories, Shionogi & Co., Toyonaka, Osaka, Japan
Shin-ichi Araki, Atsunori Kashiwagi
Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
Tetsuya Babazono, Yasuhiko Iwamoto
The Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan
Barry I. Freedman, Meredith A. Bostrom, Jessica N. Cooke, Donald W. Bowden
Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Masao Toyoda, Tomoya Umezono, Daisuke Suzuki
Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Lise Tarnow, Torben Hansen, Peter Gaede, Anders Jorsal, Oluf Pedersen
Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
Torben Hansen
Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
Daniel P. K. Ng
Department of Epidemiology and Public Health, National University of Singapore, Singapore
Minoru Ikeda, Toru Yanagimoto
Developmental Research Laboratories, Shionogi & Co., Toyonaka, Osaka, Japan
Tatsuhiko Tsunoda
Laboratory for Medical Informatics, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa, Japan
Koichi Kawai
Kawai Clinic, Tsukuba, Ibaraki, Japan
Masahito Imanishi
Division of Nephrology and Hypertension, Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan
Hyoung Doo Shin
Department of Life Science, Sogang University, Seoul, Korea
Kyong Soo Park
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea
Kyong Soo Park
Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea
Kohei Kaku
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
Ryuzo Kawamori
Department of Medicine, Metabolism, and Endocrinology, School of Medicine, Juntendo University, Tokyo, Japan
Hans-Henrik Parving, Oluf Pedersen
Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark
Hans-Henrik Parving
Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark
Oluf Pedersen
Institute of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Yusuke Nakamura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Corresponding Author

Email: smaeda@src.riken.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SM YN. Performed the experiments: SM MaK MI TY HU HDS KSP. Analyzed the data: SM BIF DPKN TT HDS KSP. Contributed reagents/materials/analysis tools: SiA TB BIF MAB JNC MT TU LT TH PG AJ DPKN KK MI DS HDS KSP AK YI KK RK HHP DWB OP. Wrote the paper: SM BIF TH OP. Performed real-time PCR: MK TY. Performed transfection experiments: MK HU. Performed European American study: BIF MAB JNC DWB. Performed Danish Type 1 diabetes study: LT AJ HHP. Performed Danish Steno-2 study: TH PG OP. Performed Singapore study: DPKN. Performed in situ hybridization: MI. Performed Korean study: HDS KSP.