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Research Article

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

  • Shuqiu Zheng equal contributor,

    equal contributor Contributed equally to this work with: Shuqiu Zheng, Erin B. D. Clabough

    Affiliation: Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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  • Erin B. D. Clabough equal contributor,

    equal contributor Contributed equally to this work with: Shuqiu Zheng, Erin B. D. Clabough

    Affiliation: Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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  • Sovan Sarkar,

    Affiliation: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Marie Futter,

    Affiliation: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • David C. Rubinsztein,

    Affiliation: Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Scott O. Zeitlin mail

    soz4n@virginia.edu

    Affiliation: Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

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  • Published: February 05, 2010
  • DOI: 10.1371/journal.pgen.1000838

About the Authors

Shuqiu Zheng, Erin B. D. Clabough, Scott O. Zeitlin
Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
Sovan Sarkar, Marie Futter, David C. Rubinsztein
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom

Corresponding Author

Email: soz4n@virginia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SZ EBDC SS MF DCR SOZ. Performed the experiments: SZ EBDC SS MF SOZ. Analyzed the data: SZ EBDC SS MF DCR SOZ. Contributed reagents/materials/analysis tools: SZ EBDC SS MF DCR SOZ. Wrote the paper: SZ EBDC SS MF DCR SOZ.