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Research Article

Activation of Mutant Enzyme Function In Vivo by Proteasome Inhibitors and Treatments that Induce Hsp70

  • Laishram R. Singh,

    Affiliation: Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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  • Sapna Gupta,

    Affiliation: Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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  • Nicholaas H. Honig,

    Affiliation: Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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  • Jan P. Kraus,

    Affiliation: Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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  • Warren D. Kruger mail

    warren.kruger@fccc.edu

    Affiliation: Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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  • Published: January 08, 2010
  • DOI: 10.1371/journal.pgen.1000807

About the Authors

Laishram R. Singh, Sapna Gupta, Nicholaas H. Honig, Warren D. Kruger
Cancer Genetics and Signaling Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
Jan P. Kraus
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America

Corresponding Author

Email: warren.kruger@fccc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LRS WDK. Performed the experiments: LRS SG NHH. Analyzed the data: LRS SG. Contributed reagents/materials/analysis tools: JPK. Wrote the paper: WDK.