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Research Article

Genome-Wide Association Study Identifies ALDH7A1 as a Novel Susceptibility Gene for Osteoporosis

  • Yan Guo equal contributor,

    equal contributor Contributed equally to this work with: Yan Guo, Li-Jun Tan

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Li-Jun Tan equal contributor,

    equal contributor Contributed equally to this work with: Yan Guo, Li-Jun Tan

    Affiliation: Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

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  • Shu-Feng Lei,

    Affiliation: School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

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  • Tie-Lin Yang,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Xiang-Ding Chen,

    Affiliation: Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

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  • Feng Zhang,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Yuan Chen,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Feng Pan,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Han Yan,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Xiaogang Liu,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Qing Tian,

    Affiliation: School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

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  • Zhi-Xin Zhang,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Qi Zhou,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Chuan Qiu,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Shan-Shan Dong,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Xiang-Hong Xu,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Yan-Fang Guo,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Xue-Zhen Zhu,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Shan-Lin Liu,

    Affiliation: Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

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  • Xiang-Li Wang,

    Affiliation: Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

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  • Xi Li,

    Affiliation: Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

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  • Yi Luo,

    Affiliation: Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China

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  • Li-Shu Zhang,

    Affiliation: School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

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  • Meng Li,

    Affiliation: Department of Orthopaedics, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Jin-Tang Wang,

    Affiliation: Department of Orthopaedics, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Ting Wen,

    Affiliation: Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China

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  • Betty Drees,

    Affiliation: School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

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  • James Hamilton,

    Affiliation: School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

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  • Christopher J. Papasian,

    Affiliation: School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America

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  • Robert R. Recker,

    Affiliation: Osteoporosis Research Center, Creighton University, Omaha, Nebraska, United States of America

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  • Xiao-Ping Song,

    Affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China

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  • Jing Cheng,

    Affiliation: National Engineering Research Center for Beijing Biochip Technology, Beijing, People's Republic of China

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  • Hong-Wen Deng mail

    dengh@umkc.edu

    Affiliations: Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China, Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China, School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America, Center of Systematic Biomedical Research, Shanghai University of Science and Technology, Shanghai, People's Republic of China

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  • Published: January 08, 2010
  • DOI: 10.1371/journal.pgen.1000806

About the Authors

Yan Guo, Tie-Lin Yang, Feng Zhang, Yuan Chen, Feng Pan, Han Yan, Xiaogang Liu, Zhi-Xin Zhang, Qi Zhou, Chuan Qiu, Shan-Shan Dong, Xiang-Hong Xu, Yan-Fang Guo, Xue-Zhen Zhu, Xiao-Ping Song, Hong-Wen Deng
Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China
Li-Jun Tan, Xiang-Ding Chen, Shan-Lin Liu, Xiang-Li Wang, Xi Li, Yi Luo, Hong-Wen Deng
Molecular and Statistical Genetics Lab, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China
Shu-Feng Lei, Qing Tian, Li-Shu Zhang, Betty Drees, James Hamilton, Christopher J. Papasian, Hong-Wen Deng
School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, United States of America
Meng Li, Jin-Tang Wang
Department of Orthopaedics, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China
Ting Wen
Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China
Robert R. Recker
Osteoporosis Research Center, Creighton University, Omaha, Nebraska, United States of America
Jing Cheng
National Engineering Research Center for Beijing Biochip Technology, Beijing, People's Republic of China
Hong-Wen Deng
Center of Systematic Biomedical Research, Shanghai University of Science and Technology, Shanghai, People's Republic of China

Corresponding Author

Email: dengh@umkc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HWD. Performed the experiments: YG LJT SFL TLY XDC FZ YC FP HY ZXZ QZ CQ SSD XHX SLL XLW XL YL. Analyzed the data: TLY XL YFG. Contributed reagents/materials/analysis tools: QT XZZ LSZ ML JTW TW RRR XPS JC. Wrote the paper: YG. Manuscript writing revision: BD, CJP, JH.