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Research Article

The Caenorhabditis elegans Werner Syndrome Protein Functions Upstream of ATR and ATM in Response to DNA Replication Inhibition and Double-Strand DNA Breaks

  • Se-Jin Lee,

    Affiliation: Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea

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  • Anton Gartner,

    Affiliation: Wellcome Trust Centre for Gene Regulation and Expression, School of Life Sciences, The University of Dundee, Dundee, United Kingdom

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  • Moonjung Hyun,

    Affiliation: Department of Life Sciences, University of Ulsan, Ulsan, Korea

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  • Byungchan Ahn,

    Affiliation: Department of Life Sciences, University of Ulsan, Ulsan, Korea

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  • Hyeon-Sook Koo mail

    kooh@yonsei.ac.kr.

    Affiliation: Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea

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  • Published: January 08, 2010
  • DOI: 10.1371/journal.pgen.1000801

About the Authors

Se-Jin Lee, Hyeon-Sook Koo
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea
Anton Gartner
Wellcome Trust Centre for Gene Regulation and Expression, School of Life Sciences, The University of Dundee, Dundee, United Kingdom
Moonjung Hyun, Byungchan Ahn
Department of Life Sciences, University of Ulsan, Ulsan, Korea

Corresponding Author

Email: kooh@yonsei.ac.kr.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJL AG BA HSK. Performed the experiments: SJL MH. Analyzed the data: SJL AG HSK. Contributed reagents/materials/analysis tools: HSK. Wrote the paper: AG HSK.