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Research Article

Modeling of Environmental Effects in Genome-Wide Association Studies Identifies SLC2A2 and HP as Novel Loci Influencing Serum Cholesterol Levels

  • Wilmar Igl mail,

    wilmar.igl@genpat.uu.se

    Affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden

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  • Åsa Johansson,

    Affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden

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  • James F. Wilson,

    Affiliation: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Sarah H. Wild,

    Affiliation: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Ozren Polašek,

    Affiliation: Andrija Štampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia

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  • Caroline Hayward,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Veronique Vitart,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Nicholas Hastie,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Pavao Rudan,

    Affiliation: Institute for Anthropological Research, Zagreb, Croatia

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  • Carsten Gnewuch,

    Affiliation: Institute for Clinical Chemistry and Laboratory Medicine, Regensburg University Medical Center, Regensburg, Germany

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  • Gerd Schmitz,

    Affiliation: Institute for Clinical Chemistry and Laboratory Medicine, Regensburg University Medical Center, Regensburg, Germany

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  • Thomas Meitinger,

    Affiliation: Helmholtz Zentrum München, GmbH, Neuherberg, Munich, Germany

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  • Peter P. Pramstaller,

    Affiliations: Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Institute of Genetic Medicine, University of Lübeck, Lübeck, Germany, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany

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  • Andrew A. Hicks,

    Affiliation: Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy

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  • Ben A. Oostra,

    Affiliation: Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Cornelia M. van Duijn,

    Affiliation: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

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  • Igor Rudan,

    Affiliations: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom, Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

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  • Alan Wright,

    Affiliation: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Harry Campbell,

    Affiliation: Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Ulf Gyllensten,

    Affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden

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  • EUROSPAN Consortium
  • Published: January 08, 2010
  • DOI: 10.1371/journal.pgen.1000798

About the Authors

Wilmar Igl, Åsa Johansson, Ulf Gyllensten
Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden
James F. Wilson, Sarah H. Wild, Igor Rudan, Alan Wright, Harry Campbell
Centre for Population Health Sciences and Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Ozren Polašek
Andrija Štampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia
Caroline Hayward, Veronique Vitart, Nicholas Hastie
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Pavao Rudan
Institute for Anthropological Research, Zagreb, Croatia
Carsten Gnewuch, Gerd Schmitz
Institute for Clinical Chemistry and Laboratory Medicine, Regensburg University Medical Center, Regensburg, Germany
Thomas Meitinger
Helmholtz Zentrum München, GmbH, Neuherberg, Munich, Germany
Peter P. Pramstaller, Andrew A. Hicks
Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy
Peter P. Pramstaller
Institute of Genetic Medicine, University of Lübeck, Lübeck, Germany
Peter P. Pramstaller
Department of Neurology, General Central Hospital, Bolzano, Italy
Peter P. Pramstaller
Department of Neurology, University of Lübeck, Lübeck, Germany
Ben A. Oostra
Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
Cornelia M. van Duijn
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Igor Rudan
Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

Corresponding Author

Email: wilmar.igl@genpat.uu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JFW NH PR TM PPP AAH BAO CMvD IR AW HC UG. Performed the experiments: ÅJ SHW OP CH VV CG. Analyzed the data: WI. Contributed reagents/materials/analysis tools: GS. Wrote the paper: WI UG.