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Research Article

Progressive Purkinje Cell Degeneration in tambaleante Mutant Mice Is a Consequence of a Missense Mutation in HERC1 E3 Ubiquitin Ligase

  • Tomoji Mashimo equal contributor,

    equal contributor Contributed equally to this work with: Tomoji Mashimo, Ouadah Hadjebi

    Affiliations: Département de Biologie du Développement, Institut Pasteur, Paris, France, Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Ouadah Hadjebi equal contributor,

    equal contributor Contributed equally to this work with: Tomoji Mashimo, Ouadah Hadjebi

    Affiliation: Departament de Ciències Fisiològiques II, IDIBELL, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain

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  • Fabiola Amair-Pinedo,

    Affiliation: Departament de Ciències Fisiològiques II, IDIBELL, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain

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  • Toshiko Tsurumi,

    Affiliation: Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Francina Langa,

    Affiliation: Département de Biologie du Développement, Institut Pasteur, Paris, France

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  • Tadao Serikawa,

    Affiliation: Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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  • Constantino Sotelo,

    Affiliation: Cátedra de Neurobiología del Desarrollo “Remedios Caro Almela”, Instituto de Neurociencias de Alicante, Universidad Miguel Hernández y CSIC, Alicante, Spain

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  • Jean-Louis Guénet mail,

    joseluisrosa@ub.edu (JLR);jlguenet@orange.fr (J-LG)

    Affiliation: Département de Biologie du Développement, Institut Pasteur, Paris, France

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  • Jose Luis Rosa mail

    joseluisrosa@ub.edu (JLR);jlguenet@orange.fr (J-LG)

    Affiliation: Departament de Ciències Fisiològiques II, IDIBELL, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain

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  • Published: December 24, 2009
  • DOI: 10.1371/journal.pgen.1000784

About the Authors

Tomoji Mashimo, Francina Langa, Jean-Louis Guénet
Département de Biologie du Développement, Institut Pasteur, Paris, France
Tomoji Mashimo, Toshiko Tsurumi, Tadao Serikawa
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Ouadah Hadjebi, Fabiola Amair-Pinedo, Jose Luis Rosa
Departament de Ciències Fisiològiques II, IDIBELL, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain
Constantino Sotelo
Cátedra de Neurobiología del Desarrollo “Remedios Caro Almela”, Instituto de Neurociencias de Alicante, Universidad Miguel Hernández y CSIC, Alicante, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TM OH TS CS JLG JLR. Performed the experiments: TM OH FAP TT FL CS JLR. Analyzed the data: TM OH FAP TT FL TS CS JLG JLR. Contributed reagents/materials/analysis tools: TM OH TS CS JLG JLR. Wrote the paper: TM OH FAP CS JLG JLR.