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Research Article

DNA Specificity Determinants Associate with Distinct Transcription Factor Functions

  • Peter C. Hollenhorst,

    Affiliation: Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America

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  • Katherine J. Chandler,

    Affiliation: Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America

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  • Rachel L. Poulsen,

    Affiliation: Department of Statistics, Brigham Young University, Provo, Utah, United States of America

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  • W. Evan Johnson,

    Affiliations: Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America, Department of Statistics, Brigham Young University, Provo, Utah, United States of America

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  • Nancy A. Speck,

    Affiliation: Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Barbara J. Graves mail

    Barbara.Graves@hci.utah.edu

    Affiliation: Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America

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  • Published: December 18, 2009
  • DOI: 10.1371/journal.pgen.1000778

About the Authors

Peter C. Hollenhorst, Katherine J. Chandler, W. Evan Johnson, Barbara J. Graves
Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
Rachel L. Poulsen, W. Evan Johnson
Department of Statistics, Brigham Young University, Provo, Utah, United States of America
Nancy A. Speck
Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: Barbara.Graves@hci.utah.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PCH KJC BJG. Performed the experiments: PCH KJC. Analyzed the data: PCH KJC RLP WEJ BJG. Contributed reagents/materials/analysis tools: NAS. Wrote the paper: PCH KJC NAS BJG.