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Research Article

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

  • Holly R. Ramage,

    Affiliations: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America, Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America

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  • Lynn E. Connolly,

    Affiliations: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America, Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America, Department of Medicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, California, United States of America

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  • Jeffery S. Cox mail

    Jeffery.Cox@ucsf.edu

    Affiliations: Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America, Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America

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  • Published: December 11, 2009
  • DOI: 10.1371/journal.pgen.1000767

About the Authors

Holly R. Ramage, Lynn E. Connolly, Jeffery S. Cox
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
Holly R. Ramage, Lynn E. Connolly, Jeffery S. Cox
Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America
Lynn E. Connolly
Department of Medicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: Jeffery.Cox@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HRR LEC JSC. Performed the experiments: HRR LEC. Analyzed the data: HRR LEC JSC. Wrote the paper: HRR LEC JSC.