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Research Article

A Mouse Model of the Human Fragile X Syndrome I304N Mutation

  • Julie B. Zang,

    Affiliation: Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America

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  • Elena D. Nosyreva,

    Affiliation: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Corinne M. Spencer,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Lenora J. Volk,

    Affiliation: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Kiran Musunuru,

    Affiliation: Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America

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  • Ru Zhong,

    Affiliation: Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America

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  • Elizabeth F. Stone,

    Affiliation: Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America

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  • Lisa A. Yuva-Paylor,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Kimberly M. Huber,

    Affiliation: Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Richard Paylor,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Jennifer C. Darnell mail,

    darneje@rockefeller.edu

    Affiliation: Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America

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  • Robert B. Darnell

    Affiliations: Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America, Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America

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  • Published: December 11, 2009
  • DOI: 10.1371/journal.pgen.1000758

About the Authors

Julie B. Zang, Kiran Musunuru, Ru Zhong, Elizabeth F. Stone, Jennifer C. Darnell, Robert B. Darnell
Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America
Elena D. Nosyreva, Lenora J. Volk, Kimberly M. Huber
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Corinne M. Spencer, Lisa A. Yuva-Paylor, Richard Paylor
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Robert B. Darnell
Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America

Corresponding Author

Email: darneje@rockefeller.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JBZ KM LAYP KH RP JCD RBD. Performed the experiments: JBZ EDN CMS LJV KM RZ EFS LAYP JCD. Analyzed the data: JBZ EDN CMS LJV KH RP JCD RBD. Wrote the paper: JBZ KH RP JCD RBD.