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Research Article

Frequent Long-Range Epigenetic Silencing of Protocadherin Gene Clusters on Chromosome 5q31 in Wilms' Tumor

  • Anthony R. Dallosso,

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Anne L. Hancock,

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Marianna Szemes,

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Kim Moorwood,

    Affiliation: Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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  • Laxmi Chilukamarri,

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Hsin-Hao Tsai,

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Abby Sarkar,

    Affiliation: Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

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  • Jonathan Barasch,

    Affiliation: Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

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  • Raisa Vuononvirta,

    Affiliation: Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Sutton, United Kingdom

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  • Chris Jones,

    Affiliation: Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Sutton, United Kingdom

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  • Kathy Pritchard-Jones,

    Affiliation: Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Sutton, United Kingdom

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  • Brigitte Royer-Pokora,

    Affiliation: Institute of Human Genetics and Anthropology, Heinrich-Heine University of Duesseldorf, Duesseldorf, Germany

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  • Sean Bong Lee,

    Affiliation: Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ceris Owen,

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Sally Malik,

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Yi Feng,

    Affiliation: Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Marcus Frank,

    Affiliation: Developmental Biology, Institute of Biology 1, University of Freiburg, Freiburg, Germany

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  • Andrew Ward,

    Affiliation: Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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  • Keith W. Brown mail,

    Keith.Brown@bristol.ac.uk (KWB); k.t.a.malik@bristol.ac.uk (KM)

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

    X
  • Karim Malik mail

    Keith.Brown@bristol.ac.uk (KWB); k.t.a.malik@bristol.ac.uk (KM)

    Affiliation: Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom

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  • Published: November 26, 2009
  • DOI: 10.1371/journal.pgen.1000745

About the Authors

Anthony R. Dallosso, Anne L. Hancock, Marianna Szemes, Laxmi Chilukamarri, Hsin-Hao Tsai, Ceris Owen, Sally Malik, Keith W. Brown, Karim Malik
Cancer and Leukaemia in Childhood – Sargent Research Unit, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
Kim Moorwood, Andrew Ward
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
Abby Sarkar, Jonathan Barasch
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
Raisa Vuononvirta, Chris Jones, Kathy Pritchard-Jones
Paediatric Oncology, Institute of Cancer Research/Royal Marsden NHS Trust, Sutton, United Kingdom
Brigitte Royer-Pokora
Institute of Human Genetics and Anthropology, Heinrich-Heine University of Duesseldorf, Duesseldorf, Germany
Sean Bong Lee
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Yi Feng
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
Marcus Frank
Developmental Biology, Institute of Biology 1, University of Freiburg, Freiburg, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K Malik. Performed the experiments: AR Dallosso, AL Hancock, M Szemes, K Moorwood, L Chilukamarri, HH Tsai, A Sarkar, C Owen, S Malik, M Frank, KW Brown, K Malik. Analyzed the data: AR Dallosso, AL Hancock, KW Brown, K Malik. Contributed reagents/materials/analysis tools: J Barasch, R Vuononvirta, K Pritchard-Jones, B Royer-Pokora, SB Lee, M Frank, A Ward. Wrote the paper: K Malik. Devised array analysis: K Moorwood, KW Brown.