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Research Article

On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies

  • Sungho Won,

    Affiliations: Department of Statistics, Chung-Ang University, Seoul, Korea, Research Center for Data Science, Chung-Ang University, Seoul, Korea

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  • Jemma B. Wilk,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Rasika A. Mathias,

    Affiliation: Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Christopher J. O'Donnell,

    Affiliations: National Heart, Lung, and Blood Institute and Framingham Heart Study, Bethesda, Maryland, United States of America, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Edwin K. Silverman,

    Affiliations: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Kathleen Barnes,

    Affiliation: Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • George T. O'Connor,

    Affiliation: Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Scott T. Weiss,

    Affiliations: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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  • Christoph Lange mail

    clange@hsph.harvard.edu

    Affiliations: Harvard Medical School, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Published: November 26, 2009
  • DOI: 10.1371/journal.pgen.1000741

About the Authors

Sungho Won
Department of Statistics, Chung-Ang University, Seoul, Korea
Sungho Won
Research Center for Data Science, Chung-Ang University, Seoul, Korea
Jemma B. Wilk
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Rasika A. Mathias
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America
Christopher J. O'Donnell
National Heart, Lung, and Blood Institute and Framingham Heart Study, Bethesda, Maryland, United States of America
Christopher J. O'Donnell
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Edwin K. Silverman, Scott T. Weiss
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Edwin K. Silverman
Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Edwin K. Silverman, Scott T. Weiss, Christoph Lange
Harvard Medical School, Boston, Massachusetts, United States of America
Kathleen Barnes
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
George T. O'Connor
Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America
Scott T. Weiss, Christoph Lange
Center for Genomic Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Christoph Lange
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

Corresponding Author

Email: clange@hsph.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SW CL. Performed the experiments: SW. Analyzed the data: SW JBW RM CJO EKS KB GTO STW. Contributed reagents/materials/analysis tools: SW. Wrote the paper: SW CL.