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Research Article

A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells

  • Je-Hyuk Lee equal contributor mail,

    equal contributor Contributed equally to this work with: Je-Hyuk Lee, In-Hyun Park

    gmc[at]harvard.edu (GMC); jehyuklee@genetics.med.harvard.edu (J-HL)

    Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • In-Hyun Park equal contributor,

    equal contributor Contributed equally to this work with: Je-Hyuk Lee, In-Hyun Park

    Affiliation: Division of Pediatric Hematology Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Yuan Gao,

    Affiliation: Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America

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  • Jin Billy Li,

    Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Zhe Li,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • George Q. Daley,

    Affiliation: Division of Pediatric Hematology Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America

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  • Kun Zhang ,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

    These authors are joint senior authors on this work.

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  • George M. Church mail

    gmc[at]harvard.edu (GMC); jehyuklee@genetics.med.harvard.edu (J-HL)

    Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    These authors are joint senior authors on this work.

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  • Published: November 13, 2009
  • DOI: 10.1371/journal.pgen.1000718

About the Authors

Je-Hyuk Lee, Jin Billy Li, George M. Church
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
In-Hyun Park, George Q. Daley
Division of Pediatric Hematology Oncology, Children's Hospital Boston, Boston, Massachusetts, United States of America
Yuan Gao
Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America
Zhe Li, Kun Zhang
Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

George M. Church is the president and CEO of the Personal Genome Project at Harvard Medical School.

Author Contributions

Conceived and designed the experiments: JHL IHP KZ. Performed the experiments: JHL IHP. Analyzed the data: JHL IHP. Contributed reagents/materials/analysis tools: JHL IHP JBL ZL KZ. Wrote the paper: JHL IHP. Performed Illumina sequencing: YG. Oversaw the generation of induced pluripotent stem cells: GQD. Oversaw the project: GMC.