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Research Article

Loss of Yeast Peroxiredoxin Tsa1p Induces Genome Instability through Activation of the DNA Damage Checkpoint and Elevation of dNTP Levels

  • Hei-Man Vincent Tang,

    Affiliation: Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People's Republic of China

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  • Kam-Leung Siu,

    Affiliation: Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People's Republic of China

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  • Chi-Ming Wong mail,

    wispwong@hkucc.hku.hk (C-MW); dyjin@hkucc.hku.hk (D-YJ)

    Affiliation: Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People's Republic of China

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  • Dong-Yan Jin mail

    wispwong@hkucc.hku.hk (C-MW); dyjin@hkucc.hku.hk (D-YJ)

    Affiliation: Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People's Republic of China

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  • Published: October 23, 2009
  • DOI: 10.1371/journal.pgen.1000697

About the Authors

Hei-Man Vincent Tang, Kam-Leung Siu, Chi-Ming Wong, Dong-Yan Jin
Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, People's Republic of China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HMVT KLS CMW DYJ. Performed the experiments: HMVT KLS CMW. Analyzed the data: HMVT CMW DYJ. Wrote the paper: HMVT CMW DYJ.